BDBM50053174 CHEMBL3318773

SMILES: CC(C)[C@@H](CS(=O)(=O)N1CCCC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1

InChI Key: InChIKey=DTXORMFVVHILOQ-GCMXZSHTSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50053174   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM50053174 (CHEMBL3318773) Show SMILES CC(C)[C@@H](CS(=O)(=O)N1CCCC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C29H36Cl2N2O5S/c1-19(2)25(18-39(37,38)32-13-4-5-14-32)33-27(20-9-11-22(30)12-10-20)24(21-7-6-8-23(31)15-21)16-29(3,28(33)36)17-26(34)35/h6-12,15,19,24-25,27H,4-5,13-14,16-18H2,1-3H3,(H,34,35)/t24-,25-,27-,29-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to human GST-thrombin-tagged MDM2 assessed as inhibition of interaction with human p53 after 1 hr by HTRF assay in presence of 15% h...				Bioorg Med Chem Lett 24: 3782-5 (2014) Article DOI: 10.1016/j.bmcl.2014.06.073 BindingDB Entry DOI: 10.7270/Q2ZC84HH
					More data for this Ligand-Target Pair