BDBM50053194 CHEMBL301956::[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-ylmethyl]-dimethyl-amine
SMILES: CN(C)Cc1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12
InChI Key: InChIKey=SPLFGEFBTYQRPO-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50053194 (CHEMBL301956 | [5-Chloro-1-(4-fluoro-phenyl)-1H-in...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11.0 | n/a | n/a | n/a | n/a | n/a | n/a |
TCG Lifesciences Ltd. Curated by ChEMBL | Assay Description Inhibition of human ERG | Eur J Med Chem 46: 618-30 (2011) Article DOI: 10.1016/j.ejmech.2010.11.042 BindingDB Entry DOI: 10.7270/Q2WQ052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50053194 (CHEMBL301956 | [5-Chloro-1-(4-fluoro-phenyl)-1H-in...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity to serotonin 5-hydroxytryptamine 2A receptors using a radioligand [3H]-ketanserin binding assay in rat cortical membranes | J Med Chem 39: 3723-38 (1996) Article DOI: 10.1021/jm960159f BindingDB Entry DOI: 10.7270/Q2CZ368W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50053194 (CHEMBL301956 | [5-Chloro-1-(4-fluoro-phenyl)-1H-in...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1 | Bioorg Med Chem Lett 13: 1829-35 (2003) BindingDB Entry DOI: 10.7270/Q2TX3FX0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50053194 (CHEMBL301956 | [5-Chloro-1-(4-fluoro-phenyl)-1H-in...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity to dopamine receptor D2 using a [3H]-spiperone binding assay in rat cortical membranes | J Med Chem 39: 3723-38 (1996) Article DOI: 10.1021/jm960159f BindingDB Entry DOI: 10.7270/Q2CZ368W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50053194 (CHEMBL301956 | [5-Chloro-1-(4-fluoro-phenyl)-1H-in...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]-prazosin binding assay in rat brain membranes | J Med Chem 39: 3723-38 (1996) Article DOI: 10.1021/jm960159f BindingDB Entry DOI: 10.7270/Q2CZ368W | |||||||||||
More data for this Ligand-Target Pair |