BDBM50054139 (R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic acid sec-butyl-methyl-amide
SMILES: CC[C@@H](C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
InChI Key: InChIKey=RAVIZVQZGXBOQO-CQSZACIVSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50054139 ((R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic a...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C]-PK-11195 from TPSO in Sprague-Dawley rat brain homogenate after 30 mins by gamma counting | J Med Chem 54: 6040-9 (2011) Article DOI: 10.1021/jm200516a BindingDB Entry DOI: 10.7270/Q2C53N16 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50054139 ((R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic a...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Macquarie University Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from wild-type human TSPO expressed in HEK293 cells after 90 mins by scintillation counting method | J Med Chem 62: 8235-8248 (2019) Article DOI: 10.1021/acs.jmedchem.9b00980 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50054139 ((R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic a...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Macquarie University Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from wild-type human TSPO expressed in HEK293 cell membranes after 90 mins by scintillation counting method | J Med Chem 62: 8235-8248 (2019) Article DOI: 10.1021/acs.jmedchem.9b00980 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50054139 ((R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic a...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Macquarie University Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from human TSPO A147T mutant expressed in HEK293 cell membranes after 90 mins by scintillation counting method | J Med Chem 62: 8235-8248 (2019) Article DOI: 10.1021/acs.jmedchem.9b00980 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50054139 ((R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic a...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Macquarie University Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from human TSPO A147T mutant expressed in HEK293 cells after 90 mins by scintillation counting method | J Med Chem 62: 8235-8248 (2019) Article DOI: 10.1021/acs.jmedchem.9b00980 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50054139 ((R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic a...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi Magna Graecia di Catanzaro Curated by ChEMBL | Assay Description Test in vitro, for potential ability to displace [3H]1 from PBR in rat brain cortex | J Med Chem 44: 1134-50 (2001) BindingDB Entry DOI: 10.7270/Q2G161KM | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |