null
SMILES: Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2nnc(s2)-c2ccccc2)c1
InChI Key: InChIKey=PMFSLJDCJWEKFR-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (Homo sapiens (Human)) | BDBM50054346 (CHEMBL3319369 | US9522881, 11a-14 (L97M73) | US984...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.79E+3 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description The inhibition assays were performed at 25° C. in 50 mM 3,3-dimethylglutarate buffer, pH 7.0, containing 1 mM EDTA with an ionic strength of 0.15M ad... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (Homo sapiens (Human)) | BDBM50054346 (CHEMBL3319369 | US9522881, 11a-14 (L97M73) | US984...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.79E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description PTP assays were conducted as previously described in Kontaridis et al., J Biol Chem. 2006; 281:6785-6792, using para-nitrophenyl phosphate (pNPP, obt... | US Patent US9844535 (2017) BindingDB Entry DOI: 10.7270/Q2NZ89X1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50054346 (CHEMBL3319369 | US9522881, 11a-14 (L97M73) | US984...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.79E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP2 (unknown origin) using p-nitrophenyl phosphate substrate by microplate spectrophotometry | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
More data for this Ligand-Target Pair |