BDBM50054370 2-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione::CHEMBL46471

SMILES: COc1ccccc1N1CCN(Cn2c(O)c3CCCn3c2=O)CC1

InChI Key: InChIKey=LVQFRSXUJYYCIN-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50054370   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50054370 (2-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-tetr...) Show SMILES COc1ccccc1N1CCN(Cn2c(O)c3CCCn3c2=O)CC1 Show InChI InChI=1S/C18H24N4O3/c1-25-16-7-3-2-5-14(16)20-11-9-19(10-12-20)13-22-17(23)15-6-4-8-21(15)18(22)24/h2-3,5,7,23H,4,6,8-13H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	34.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Complutense Curated by ChEMBL					Assay Description Binding affinity towards rat 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT radioligand.				J Med Chem 39: 4439-50 (1996) Article DOI: 10.1021/jm960416g BindingDB Entry DOI: 10.7270/Q2WS8SBN
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50054370 (2-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-tetr...) Show SMILES COc1ccccc1N1CCN(Cn2c(O)c3CCCn3c2=O)CC1 Show InChI InChI=1S/C18H24N4O3/c1-25-16-7-3-2-5-14(16)20-11-9-19(10-12-20)13-22-17(23)15-6-4-8-21(15)18(22)24/h2-3,5,7,23H,4,6,8-13H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Complutense Curated by ChEMBL					Assay Description In vitro binding affinity against 5-hydroxytryptamine 1A receptor of rat cerebral cortex using [3H]8-OH-DPAT as radioligand.				J Med Chem 40: 1648-56 (1997) Article DOI: 10.1021/jm960744g BindingDB Entry DOI: 10.7270/Q2K35V96
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50054370 (2-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-tetr...) Show SMILES COc1ccccc1N1CCN(Cn2c(O)c3CCCn3c2=O)CC1 Show InChI InChI=1S/C18H24N4O3/c1-25-16-7-3-2-5-14(16)20-11-9-19(10-12-20)13-22-17(23)15-6-4-8-21(15)18(22)24/h2-3,5,7,23H,4,6,8-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Complutense Curated by ChEMBL					Assay Description Binding affinity towards dopamine receptor D2 using [3H]-raclopride radioligand.				J Med Chem 39: 4439-50 (1996) Article DOI: 10.1021/jm960416g BindingDB Entry DOI: 10.7270/Q2WS8SBN
					More data for this Ligand-Target Pair