BDBM50056448 CHEMBL2371221::N-(1-Carbamoyl-2-phenyl-ethyl)-3-{[(2R,5R)-2-(1H-indol-3-ylmethyl)-2-methyl-3,14-dioxo-1,4diaza-cyclotetradecane-5-carbonyl]-amino}-succinamic acid
SMILES: C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@@H](NC1=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
InChI Key: InChIKey=HJERLDHULRYYBI-KBSIUYBGSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cholecystokinin receptor (Homo sapiens (Human)) | BDBM50056448 (CHEMBL2371221 | N-(1-Carbamoyl-2-phenyl-ethyl)-3-{...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM Curated by ChEMBL | Assay Description Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor | J Med Chem 40: 647-58 (1997) Article DOI: 10.1021/jm9603072 BindingDB Entry DOI: 10.7270/Q2PG1SDX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CCKBR (RAT) | BDBM50056448 (CHEMBL2371221 | N-(1-Carbamoyl-2-phenyl-ethyl)-3-{...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM Curated by ChEMBL | Assay Description Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells | J Med Chem 40: 647-58 (1997) Article DOI: 10.1021/jm9603072 BindingDB Entry DOI: 10.7270/Q2PG1SDX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholecystokinin A receptor (Cavia porcellus) | BDBM50056448 (CHEMBL2371221 | N-(1-Carbamoyl-2-phenyl-ethyl)-3-{...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM Curated by ChEMBL | Assay Description Inhibition of [3H]pCCK-8 binding to Cholecystokinin type A receptor of Guinea pig pancreatic membranes | J Med Chem 40: 647-58 (1997) Article DOI: 10.1021/jm9603072 BindingDB Entry DOI: 10.7270/Q2PG1SDX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CCKBR (RAT) | BDBM50056448 (CHEMBL2371221 | N-(1-Carbamoyl-2-phenyl-ethyl)-3-{...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
INSERM Curated by ChEMBL | Assay Description Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor | J Med Chem 40: 647-58 (1997) Article DOI: 10.1021/jm9603072 BindingDB Entry DOI: 10.7270/Q2PG1SDX | |||||||||||
More data for this Ligand-Target Pair |