BDBM50058179 (4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid 2-(4-methyl-piperidin-1-yl)-ethyl ester::CHEMBL49266
SMILES: COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCC(C)CC1
InChI Key: InChIKey=NNIMLCLPNLSNFC-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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HTR4 (RAT) | BDBM50058179 ((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS-BIOCIS Curated by ChEMBL | Assay Description Binding affinity (Ki+/-SEM) against 5-hydroxytryptamine 4 receptor from cheng Prusoff equation by using [3H]-GR 113808 in rat striatum | J Med Chem 40: 1755-61 (1997) Article DOI: 10.1021/jm960853v BindingDB Entry DOI: 10.7270/Q2NS0T0C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR4 (GUINEA PIG) | BDBM50058179 ((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
CNRS-BIOCIS Curated by ChEMBL | Assay Description concentration which gave a 50% increase in the response to electrical stimulation against 5-hydroxytryptamine 4 receptor in the guinea pig ileum. Act... | J Med Chem 40: 1755-61 (1997) Article DOI: 10.1021/jm960853v BindingDB Entry DOI: 10.7270/Q2NS0T0C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR4 (GUINEA PIG) | BDBM50058179 ((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS-BIOCIS Curated by ChEMBL | Assay Description The antagonist activity was calculated as the concentration which produced a 50% reduction against 5-hydroxytryptamine 4 receptor in guinea pig ileum... | J Med Chem 40: 1755-61 (1997) Article DOI: 10.1021/jm960853v BindingDB Entry DOI: 10.7270/Q2NS0T0C | |||||||||||
More data for this Ligand-Target Pair |