BDBM50058332 CHEMBL299496::methyl 10,23-di(ethylsulfanylmethyl)-16-hydroxy-15-methyl-3-oxo-(15S,16R)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1(26),2(6),7(27),8,10,12,20(25),21,23-nonaene-16-carboxylate
SMILES: CCSCc1ccc2n3C4C[C@](O)(C(=O)OC)[C@](C)(O4)n4c5ccc(CSCC)cc5c5c6CNC(=O)c6c(c2c1)c3c45
InChI Key: InChIKey=SCMLRESZJCKCTC-SVQPHZEZSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Myosin light chain kinase, smooth muscle (Gallus gallus (chicken)) | BDBM50058332 (CHEMBL299496 | methyl 10,23-di(ethylsulfanylmethyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of Smooth muscle myosin light chain kinase of chicken gizzard | J Med Chem 40: 1863-9 (1997) Article DOI: 10.1021/jm970031d BindingDB Entry DOI: 10.7270/Q2W95891 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50058332 (CHEMBL299496 | methyl 10,23-di(ethylsulfanylmethyl...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd. Curated by ChEMBL | Assay Description Ability to inhibit human trk A tyrosine kinase expressed in baculovirus using ELISA based enzyme assay was determined | J Med Chem 40: 1863-9 (1997) Article DOI: 10.1021/jm970031d BindingDB Entry DOI: 10.7270/Q2W95891 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PAK 1 (Mus musculus) | BDBM50058332 (CHEMBL299496 | methyl 10,23-di(ethylsulfanylmethyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
PAK Research Center Curated by ChEMBL | Assay Description Inhibition of PAK1 in v-Ha-RAS-transformed mouse NIH/3T3 cells incubated for 1 hr by immunoblot analysis | Eur J Med Chem 142: 229-243 (2017) Article DOI: 10.1016/j.ejmech.2017.07.043 BindingDB Entry DOI: 10.7270/Q21J9DG3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human)) | BDBM50058332 (CHEMBL299496 | methyl 10,23-di(ethylsulfanylmethyl...) | PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
PAK Research Center Curated by ChEMBL | Assay Description Inhibition of flag-tagged MLK3 (unknown origin) expressed in human HeLa cells assessed as reduction in enzyme autophosphorylation incubated for 20 mi... | Eur J Med Chem 142: 229-243 (2017) Article DOI: 10.1016/j.ejmech.2017.07.043 BindingDB Entry DOI: 10.7270/Q21J9DG3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclic AMP-dependent protein kinase (PKA) (Oryctolagus cuniculus (Rabbit)) | BDBM50058332 (CHEMBL299496 | methyl 10,23-di(ethylsulfanylmethyl...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of cAMP dependent Protein kinase A of rabbit Skeletal Muscle. | J Med Chem 40: 1863-9 (1997) Article DOI: 10.1021/jm970031d BindingDB Entry DOI: 10.7270/Q2W95891 | |||||||||||
More data for this Ligand-Target Pair |