BDBM50058763 CHEMBL3335418

SMILES: C[C@H]1CN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C(F)(F)F)CCN1Cc1cccnc1

InChI Key: InChIKey=BAECAPJWZMSHMJ-IBGZPJMESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50058763   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50058763 (CHEMBL3335418) Show SMILES C[C@H]1CN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C(F)(F)F)CCN1Cc1cccnc1 |r| Show InChI InChI=1S/C26H27F3N4O/c1-19-16-32(13-14-33(19)18-21-3-2-12-30-15-21)17-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay				Bioorg Med Chem 22: 5513-29 (2014) Article DOI: 10.1016/j.bmc.2014.07.020 BindingDB Entry DOI: 10.7270/Q24J0GSG
					More data for this Ligand-Target Pair