BDBM50058767 CHEMBL3335414

SMILES: CN(CCN(C)Cc1cccnc1)Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=WLYHQGRWWJUGPS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50058767   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50058767 (CHEMBL3335414) Show SMILES CN(CCN(C)Cc1cccnc1)Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H27F3N4O/c1-31(14-15-32(2)18-20-4-3-13-29-16-20)17-19-5-7-21(8-6-19)24(33)30-23-11-9-22(10-12-23)25(26,27)28/h3-13,16H,14-15,17-18H2,1-2H3,(H,30,33)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay				Bioorg Med Chem 22: 5513-29 (2014) Article DOI: 10.1016/j.bmc.2014.07.020 BindingDB Entry DOI: 10.7270/Q24J0GSG
					More data for this Ligand-Target Pair