BDBM50058971 CHEMBL304338::[3-(2,5-Dioxo-3-phenyl-imidazolidine-1-sulfonyl)-phenyl]-acetic acid methyl ester

SMILES: COC(=O)Cc1cccc(c1)S(=O)(=O)N1C(=O)CN(C1=O)c1ccccc1

InChI Key: InChIKey=LOQFKRHVSLFGHY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50058971   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM50058971 (CHEMBL304338 | [3-(2,5-Dioxo-3-phenyl-imidazolidin...) Show SMILES COC(=O)Cc1cccc(c1)S(=O)(=O)N1C(=O)CN(C1=O)c1ccccc1 Show InChI InChI=1S/C18H16N2O6S/c1-26-17(22)11-13-6-5-9-15(10-13)27(24,25)20-16(21)12-19(18(20)23)14-7-3-2-4-8-14/h2-10H,11-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human heart chymase in vitro.				J Med Chem 40: 2156-63 (1997) Article DOI: 10.1021/jm960793t BindingDB Entry DOI: 10.7270/Q2QJ7GDG
					More data for this Ligand-Target Pair
Alpha-chymotrypsin (Bos taurus (bovine))	BDBM50058971 (CHEMBL304338 | [3-(2,5-Dioxo-3-phenyl-imidazolidin...) Show SMILES COC(=O)Cc1cccc(c1)S(=O)(=O)N1C(=O)CN(C1=O)c1ccccc1 Show InChI InChI=1S/C18H16N2O6S/c1-26-17(22)11-13-6-5-9-15(10-13)27(24,25)20-16(21)12-19(18(20)23)14-7-3-2-4-8-14/h2-10H,11-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against bovine pancreas alpha-chymotrypsin in vitro				J Med Chem 40: 2156-63 (1997) Article DOI: 10.1021/jm960793t BindingDB Entry DOI: 10.7270/Q2QJ7GDG
					More data for this Ligand-Target Pair
Cathepsin G (Homo sapiens (Human))	BDBM50058971 (CHEMBL304338 | [3-(2,5-Dioxo-3-phenyl-imidazolidin...) Show SMILES COC(=O)Cc1cccc(c1)S(=O)(=O)N1C(=O)CN(C1=O)c1ccccc1 Show InChI InChI=1S/C18H16N2O6S/c1-26-17(22)11-13-6-5-9-15(10-13)27(24,25)20-16(21)12-19(18(20)23)14-7-3-2-4-8-14/h2-10H,11-12H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human neutrophil cathepsin G.				J Med Chem 40: 2156-63 (1997) Article DOI: 10.1021/jm960793t BindingDB Entry DOI: 10.7270/Q2QJ7GDG
					More data for this Ligand-Target Pair