BDBM50059114 2-(4-Methoxy-phenyl)-5-methyl-1H-[1,8]naphthyridin-4-one::CHEMBL49431

SMILES: COc1ccc(cc1)-c1cc(O)c2c(C)ccnc2n1

InChI Key: InChIKey=RDWYUHASFATBBC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50059114   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tubulin (Sus scrofa (Pig))	BDBM50059114 (2-(4-Methoxy-phenyl)-5-methyl-1H-[1,8]naphthyridin...) Show SMILES COc1ccc(cc1)-c1cc(O)c2c(C)ccnc2n1 Show InChI InChI=1S/C16H14N2O2/c1-10-7-8-17-16-15(10)14(19)9-13(18-16)11-3-5-12(20-2)6-4-11/h3-9H,1-2H3,(H,17,18,19)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	8.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization interacting at the colchicine binding site.				J Med Chem 43: 167-76 (2000) BindingDB Entry DOI: 10.7270/Q2CV4JZB
					More data for this Ligand-Target Pair
Tubulin (Bos taurus)	BDBM50059114 (2-(4-Methoxy-phenyl)-5-methyl-1H-[1,8]naphthyridin...) Show SMILES COc1ccc(cc1)-c1cc(O)c2c(C)ccnc2n1 Show InChI InChI=1S/C16H14N2O2/c1-10-7-8-17-16-15(10)14(19)9-13(18-16)11-3-5-12(20-2)6-4-11/h3-9H,1-2H3,(H,17,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill 27599 Curated by ChEMBL					Assay Description Inhibition of bovine tubulin polymerization				J Med Chem 40: 2266-75 (1997) Article DOI: 10.1021/jm960858s BindingDB Entry DOI: 10.7270/Q26M35ZF
					More data for this Ligand-Target Pair