BDBM50059249 CHEMBL3393313::US9868720, No. 6

SMILES: CCc1ccnc(Nc2cc(nc(C)n2)C2CCCN(C2)C(=O)c2ccccc2)c1

InChI Key: InChIKey=BQTLKRXKSBFWID-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50059249   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50059249 (CHEMBL3393313 | US9868720, No. 6) Show SMILES CCc1ccnc(Nc2cc(nc(C)n2)C2CCCN(C2)C(=O)c2ccccc2)c1 Show InChI InChI=1S/C24H27N5O/c1-3-18-11-12-25-22(14-18)28-23-15-21(26-17(2)27-23)20-10-7-13-29(16-20)24(30)19-8-5-4-6-9-19/h4-6,8-9,11-12,14-15,20H,3,7,10,13,16H2,1-2H3,(H,25,26,27,28)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	195	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2J38VWN
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50059249 (CHEMBL3393313 | US9868720, No. 6) Show SMILES CCc1ccnc(Nc2cc(nc(C)n2)C2CCCN(C2)C(=O)c2ccccc2)c1 Show InChI InChI=1S/C24H27N5O/c1-3-18-11-12-25-22(14-18)28-23-15-21(26-17(2)27-23)20-10-7-13-29(16-20)24(30)19-8-5-4-6-9-19/h4-6,8-9,11-12,14-15,20H,3,7,10,13,16H2,1-2H3,(H,25,26,27,28)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	195	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of DLK (unknown origin)				J Med Chem 58: 401-18 (2015) Article DOI: 10.1021/jm5013984 BindingDB Entry DOI: 10.7270/Q22J6DJ5
					More data for this Ligand-Target Pair