BDBM50059309 CHEMBL3393446
SMILES: N#CCC1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
InChI Key: InChIKey=OVLGSAZYDZSQMN-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase MST2 (Homo sapiens (Human)) | BDBM50059309 (CHEMBL3393446) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 196 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant MST2 using Ser/Thr peptide 7 substrate after 45 mins by Z-Lyte assay | J Med Chem 58: 419-32 (2015) Article DOI: 10.1021/jm5014055 BindingDB Entry DOI: 10.7270/Q2XS5X2W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human)) | BDBM50059309 (CHEMBL3393446) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of GST-tagged truncated human recombinant LRRK2 using fluorescein-labeled LRRKtide peptide substrate incubated for 2 hrs | J Med Chem 58: 419-32 (2015) Article DOI: 10.1021/jm5014055 BindingDB Entry DOI: 10.7270/Q2XS5X2W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human)) | BDBM50059309 (CHEMBL3393446) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of full length LRRK2 (unknown origin) expressed in HEK293 cells assessed as reduction in S935 phosphorylation incubated for 90 mins by ELI... | J Med Chem 58: 419-32 (2015) Article DOI: 10.1021/jm5014055 BindingDB Entry DOI: 10.7270/Q2XS5X2W | |||||||||||
More data for this Ligand-Target Pair |