BindingDB logo
myBDB logout

BDBM50060633 (S)-2-Amino-3-(6-methyl-3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-propionic acid::CHEMBL120808

SMILES: Cc1nn(C[C@H](N)C(O)=O)c(=O)[nH]c1=O

InChI Key: InChIKey=SNQRPZWKEMQXLW-BYPYZUCNSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50060633   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50060633
PNG
((S)-2-Amino-3-(6-methyl-3,5-dioxo-4,5-dihydro-3H-[...)
Show SMILES Cc1nn(C[C@H](N)C(O)=O)c(=O)[nH]c1=O
Show InChI InChI=1S/C7H10N4O4/c1-3-5(12)9-7(15)11(10-3)2-4(8)6(13)14/h4H,2,8H2,1H3,(H,13,14)(H,9,12,15)/t4-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
89n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 4 expressed in HEK293 cells


J Med Chem 40: 3645-50 (1997)


Article DOI: 10.1021/jm9702387
BindingDB Entry DOI: 10.7270/Q28G8MCB
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50060633
PNG
((S)-2-Amino-3-(6-methyl-3,5-dioxo-4,5-dihydro-3H-[...)
Show SMILES Cc1nn(C[C@H](N)C(O)=O)c(=O)[nH]c1=O
Show InChI InChI=1S/C7H10N4O4/c1-3-5(12)9-7(15)11(10-3)2-4(8)6(13)14/h4H,2,8H2,1H3,(H,13,14)(H,9,12,15)/t4-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
240n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 1 expressed in HEK293 cells


J Med Chem 40: 3645-50 (1997)


Article DOI: 10.1021/jm9702387
BindingDB Entry DOI: 10.7270/Q28G8MCB
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50060633
PNG
((S)-2-Amino-3-(6-methyl-3,5-dioxo-4,5-dihydro-3H-[...)
Show SMILES Cc1nn(C[C@H](N)C(O)=O)c(=O)[nH]c1=O
Show InChI InChI=1S/C7H10N4O4/c1-3-5(12)9-7(15)11(10-3)2-4(8)6(13)14/h4H,2,8H2,1H3,(H,13,14)(H,9,12,15)/t4-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
372n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cells


J Med Chem 40: 3645-50 (1997)


Article DOI: 10.1021/jm9702387
BindingDB Entry DOI: 10.7270/Q28G8MCB
More data for this
Ligand-Target Pair
Grik5


(Homo sapiens (Human))
BDBM50060633
PNG
((S)-2-Amino-3-(6-methyl-3,5-dioxo-4,5-dihydro-3H-[...)
Show SMILES Cc1nn(C[C@H](N)C(O)=O)c(=O)[nH]c1=O
Show InChI InChI=1S/C7H10N4O4/c1-3-5(12)9-7(15)11(10-3)2-4(8)6(13)14/h4H,2,8H2,1H3,(H,13,14)(H,9,12,15)/t4-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.15E+3n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cells


J Med Chem 40: 3645-50 (1997)


Article DOI: 10.1021/jm9702387
BindingDB Entry DOI: 10.7270/Q28G8MCB
More data for this
Ligand-Target Pair