BDBM50061458 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone::CHEMBL63804

SMILES: [#8-]-[n+]1ccc(-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#6]-[#6]-c3cccnc-23)cc1

InChI Key: InChIKey=SQAJXBGZLZTIBS-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50061458   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50061458 (1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...) Show SMILES [#8-]-[n+]1ccc(-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#6]-[#6]-c3cccnc-23)cc1 Show InChI InChI=1S/C26H24ClN3O2/c27-22-5-6-23-21(17-22)4-3-20-2-1-11-28-26(20)25(23)19-9-12-29(13-10-19)24(31)16-18-7-14-30(32)15-8-18/h1-2,5-8,11,14-15,17H,3-4,9-10,12-13,16H2	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Compound was tested for the inhibition of Farnesyltransferase				J Med Chem 40: 4290-301 (1998) Article DOI: 10.1021/jm970464g BindingDB Entry DOI: 10.7270/Q2NC60B2
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50061458 (1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...) Show SMILES [#8-]-[n+]1ccc(-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#6]-[#6]-c3cccnc-23)cc1 Show InChI InChI=1S/C26H24ClN3O2/c27-22-5-6-23-21(17-22)4-3-20-2-1-11-28-26(20)25(23)19-9-12-29(13-10-19)24(31)16-18-7-14-30(32)15-8-18/h1-2,5-8,11,14-15,17H,3-4,9-10,12-13,16H2	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Farnesyl protein transferase				J Med Chem 42: 2125-35 (1999) Article DOI: 10.1021/jm990030g BindingDB Entry DOI: 10.7270/Q2ZS2VP9
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50061458 (1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...) Show SMILES [#8-]-[n+]1ccc(-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#6]-[#6]-c3cccnc-23)cc1 Show InChI InChI=1S/C26H24ClN3O2/c27-22-5-6-23-21(17-22)4-3-20-2-1-11-28-26(20)25(23)19-9-12-29(13-10-19)24(31)16-18-7-14-30(32)15-8-18/h1-2,5-8,11,14-15,17H,3-4,9-10,12-13,16H2	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human farnesyltransferase				J Med Chem 40: 4103-12 (1998) Article DOI: 10.1021/jm970291v BindingDB Entry DOI: 10.7270/Q2T152R0
					More data for this Ligand-Target Pair