BDBM50061555 8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine::CHEMBL73074

SMILES: COc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(C)CC1

InChI Key: InChIKey=VTMVQXBSLJXPIT-UHFFFAOYSA-N

Data: 10 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50061555   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(1A) dopamine receptor (RAT)	BDBM50061555 (8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...) Show SMILES COc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(C)CC1 |c:14| Show InChI InChI=1S/C19H22N4O/c1-22-9-11-23(12-10-22)19-15-5-3-4-6-16(15)20-17-8-7-14(24-2)13-18(17)21-19/h3-8,13,20H,9-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibitory binding of [3H]-SCH-23,390 to Dopamine receptor D1 in membranes from rat corpus striatum				J Med Chem 40: 4146-53 (1998) Article DOI: 10.1021/jm9704457 BindingDB Entry DOI: 10.7270/Q2DV1J1D
					More data for this Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat))	BDBM50061555 (8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...) Show SMILES COc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(C)CC1 |c:14| Show InChI InChI=1S/C19H22N4O/c1-22-9-11-23(12-10-22)19-15-5-3-4-6-16(15)20-17-8-7-14(24-2)13-18(17)21-19/h3-8,13,20H,9-12H2,1-2H3	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of [3H]-mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranes				J Med Chem 40: 4146-53 (1998) Article DOI: 10.1021/jm9704457 BindingDB Entry DOI: 10.7270/Q2DV1J1D
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50061555 (8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...) Show SMILES COc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(C)CC1 |c:14| Show InChI InChI=1S/C19H22N4O/c1-22-9-11-23(12-10-22)19-15-5-3-4-6-16(15)20-17-8-7-14(24-2)13-18(17)21-19/h3-8,13,20H,9-12H2,1-2H3	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibitory binding of [3H]-pirenzepine to human Muscarinic acetylcholine receptor M1 in membranes from CHO-K1 cells				J Med Chem 40: 4146-53 (1998) Article DOI: 10.1021/jm9704457 BindingDB Entry DOI: 10.7270/Q2DV1J1D
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50061555 (8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...) Show SMILES COc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(C)CC1 |c:14| Show InChI InChI=1S/C19H22N4O/c1-22-9-11-23(12-10-22)19-15-5-3-4-6-16(15)20-17-8-7-14(24-2)13-18(17)21-19/h3-8,13,20H,9-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of [3H]-ketanserin binding to 5-hydroxytryptamine 2A receptor from rat brain				J Med Chem 40: 4146-53 (1998) Article DOI: 10.1021/jm9704457 BindingDB Entry DOI: 10.7270/Q2DV1J1D
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50061555 (8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...) Show SMILES COc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(C)CC1 |c:14| Show InChI InChI=1S/C19H22N4O/c1-22-9-11-23(12-10-22)19-15-5-3-4-6-16(15)20-17-8-7-14(24-2)13-18(17)21-19/h3-8,13,20H,9-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]-SCH-23,390 as radioligand				J Med Chem 42: 2235-44 (1999) Article DOI: 10.1021/jm991005d BindingDB Entry DOI: 10.7270/Q2KH0MH7
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50061555 (8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...) Show SMILES COc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(C)CC1 |c:14| Show InChI InChI=1S/C19H22N4O/c1-22-9-11-23(12-10-22)19-15-5-3-4-6-16(15)20-17-8-7-14(24-2)13-18(17)21-19/h3-8,13,20H,9-12H2,1-2H3	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Inhibition of binding of 1.0 nM [3H]-pirenzepine to cloned human Muscarinic acetylcholine receptor M1 expressed in membranes from CHO-K1 cells				J Med Chem 42: 2235-44 (1999) Article DOI: 10.1021/jm991005d BindingDB Entry DOI: 10.7270/Q2KH0MH7
					More data for this Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat))	BDBM50061555 (8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...) Show SMILES COc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(C)CC1 |c:14| Show InChI InChI=1S/C19H22N4O/c1-22-9-11-23(12-10-22)19-15-5-3-4-6-16(15)20-17-8-7-14(24-2)13-18(17)21-19/h3-8,13,20H,9-12H2,1-2H3	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Binding affinity towards 5-HT2C receptor from rat using [3H]-mesulergine as radioligand				J Med Chem 42: 2235-44 (1999) Article DOI: 10.1021/jm991005d BindingDB Entry DOI: 10.7270/Q2KH0MH7
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50061555 (8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...) Show SMILES COc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(C)CC1 |c:14| Show InChI InChI=1S/C19H22N4O/c1-22-9-11-23(12-10-22)19-15-5-3-4-6-16(15)20-17-8-7-14(24-2)13-18(17)21-19/h3-8,13,20H,9-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 2A receptor from rat frontal cortex using [3H]-ketanserin as radioligand				J Med Chem 42: 2235-44 (1999) Article DOI: 10.1021/jm991005d BindingDB Entry DOI: 10.7270/Q2KH0MH7
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50061555 (8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...) Show SMILES COc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(C)CC1 |c:14| Show InChI InChI=1S/C19H22N4O/c1-22-9-11-23(12-10-22)19-15-5-3-4-6-16(15)20-17-8-7-14(24-2)13-18(17)21-19/h3-8,13,20H,9-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Göteborg Curated by ChEMBL					Assay Description Binding affinity towards Dopamine receptor D2 of rat corpus striatum using [3H]-spiperone as radioligand				J Med Chem 42: 2235-44 (1999) Article DOI: 10.1021/jm991005d BindingDB Entry DOI: 10.7270/Q2KH0MH7
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50061555 (8-Methoxy-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[...) Show SMILES COc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(C)CC1 |c:14| Show InChI InChI=1S/C19H22N4O/c1-22-9-11-23(12-10-22)19-15-5-3-4-6-16(15)20-17-8-7-14(24-2)13-18(17)21-19/h3-8,13,20H,9-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibitory binding of [3H]-spiperone to Dopamine receptor D2 in membranes from rat corpus striatum				J Med Chem 40: 4146-53 (1998) Article DOI: 10.1021/jm9704457 BindingDB Entry DOI: 10.7270/Q2DV1J1D
					More data for this Ligand-Target Pair