null

SMILES: Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1

InChI Key: InChIKey=PHEIFHNTKMTUTE-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50061628   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM50061628 (CHEMBL3394067 | US9321756, 24) Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1 Show InChI InChI=1S/C19H18N6OS/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	44.4	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9321756 (2016) BindingDB Entry DOI: 10.7270/Q2W094S2
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50061628 (CHEMBL3394067 | US9321756, 24) Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1 Show InChI InChI=1S/C19H18N6OS/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17.4	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9321756 (2016) BindingDB Entry DOI: 10.7270/Q2W094S2
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50061628 (CHEMBL3394067 | US9321756, 24) Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1 Show InChI InChI=1S/C19H18N6OS/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	94.9	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9321756 (2016) BindingDB Entry DOI: 10.7270/Q2W094S2
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50061628 (CHEMBL3394067 | US9321756, 24) Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1 Show InChI InChI=1S/C19H18N6OS/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	58.7	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9321756 (2016) BindingDB Entry DOI: 10.7270/Q2W094S2
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50061628 (CHEMBL3394067 | US9321756, 24) Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1 Show InChI InChI=1S/C19H18N6OS/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9321756 (2016) BindingDB Entry DOI: 10.7270/Q2W094S2
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM50061628 (CHEMBL3394067 | US9321756, 24) Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1 Show InChI InChI=1S/C19H18N6OS/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...				Bioorg Med Chem Lett 25: 775-80 (2015) Article DOI: 10.1016/j.bmcl.2014.12.091 BindingDB Entry DOI: 10.7270/Q2WQ05G8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50061628 (CHEMBL3394067 | US9321756, 24) Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1 Show InChI InChI=1S/C19H18N6OS/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...				Bioorg Med Chem Lett 25: 775-80 (2015) Article DOI: 10.1016/j.bmcl.2014.12.091 BindingDB Entry DOI: 10.7270/Q2WQ05G8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50061628 (CHEMBL3394067 | US9321756, 24) Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1 Show InChI InChI=1S/C19H18N6OS/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	152	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PIM1 in human U2OS cells assessed as phosphorylation of BAD				Bioorg Med Chem Lett 25: 775-80 (2015) Article DOI: 10.1016/j.bmcl.2014.12.091 BindingDB Entry DOI: 10.7270/Q2WQ05G8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50061628 (CHEMBL3394067 | US9321756, 24) Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1 Show InChI InChI=1S/C19H18N6OS/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...				Bioorg Med Chem Lett 25: 775-80 (2015) Article DOI: 10.1016/j.bmcl.2014.12.091 BindingDB Entry DOI: 10.7270/Q2WQ05G8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50061628 (CHEMBL3394067 | US9321756, 24) Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1 Show InChI InChI=1S/C19H18N6OS/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.57E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PIM2 in human U2OS cells assessed as phosphorylation of BAD				Bioorg Med Chem Lett 25: 775-80 (2015) Article DOI: 10.1016/j.bmcl.2014.12.091 BindingDB Entry DOI: 10.7270/Q2WQ05G8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM50061628 (CHEMBL3394067 | US9321756, 24) Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1 Show InChI InChI=1S/C19H18N6OS/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.59	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9321756 (2016) BindingDB Entry DOI: 10.7270/Q2W094S2
					More data for this Ligand-Target Pair