BDBM50062261 CHEMBL829::Dimethyl-(2-methyl-3-phenothiazin-10-yl-propyl)-amine::Methylpromazine::N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine::TRIMEPRAZINE::Temaril

SMILES: CC(CN(C)C)CN1c2ccccc2Sc2ccccc12

InChI Key: InChIKey=ZZHLYYDVIOPZBE-UHFFFAOYSA-N

Data: 2 KI  2 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50062261   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H1 receptor (RAT)	BDBM50062261 (CHEMBL829 | Dimethyl-(2-methyl-3-phenothiazin-10-y...) Show SMILES CC(CN(C)C)CN1c2ccccc2Sc2ccccc12 Show InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP Ki Database									Proc Natl Acad Sci U S A 75: 6290-4 (1978) Article DOI: 10.1073/pnas.75.12.6290 BindingDB Entry DOI: 10.7270/Q2FN14P6
					More data for this Ligand-Target Pair
Trypanothione reductase (Trypanosoma cruzi)	BDBM50062261 (CHEMBL829 | Dimethyl-(2-methyl-3-phenothiazin-10-y...) Show SMILES CC(CN(C)C)CN1c2ccccc2Sc2ccccc12 Show InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	1.27E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibitory activity against recombinant Trypanosoma cruzi (T. cruzi) Trypanothione reductase (linear competitive type)				J Med Chem 41: 148-56 (1998) Article DOI: 10.1021/jm960814j BindingDB Entry DOI: 10.7270/Q2ZP457X
					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM50062261 (CHEMBL829 | Dimethyl-(2-methyl-3-phenothiazin-10-y...) Show SMILES CC(CN(C)C)CN1c2ccccc2Sc2ccccc12 Show InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...				Drug Metab Dispos 40: 2332-41 (2012) Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M
					More data for this Ligand-Target Pair
Serum albumin (Bos taurus)	BDBM50062261 (CHEMBL829 | Dimethyl-(2-methyl-3-phenothiazin-10-y...) Show SMILES CC(CN(C)C)CN1c2ccccc2Sc2ccccc12 Show InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	2.04E+4	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to bovine serum albumin by circular dichroic probe technique				J Med Chem 20: 430-9 (1977) Article DOI: 10.1021/jm00213a022 BindingDB Entry DOI: 10.7270/Q2ZC85WV
					More data for this Ligand-Target Pair
Trypanothione reductase (Trypanosoma cruzi)	BDBM50062261 (CHEMBL829 | Dimethyl-(2-methyl-3-phenothiazin-10-y...) Show SMILES CC(CN(C)C)CN1c2ccccc2Sc2ccccc12 Show InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.49E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductase				J Med Chem 41: 148-56 (1998) Article DOI: 10.1021/jm960814j BindingDB Entry DOI: 10.7270/Q2ZP457X
					More data for this Ligand-Target Pair