BDBM50062666 2-Amino-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide::CHEMBL134863

SMILES: Nc1ncc(C(=O)Nc2cc(Cl)cc(Cl)c2)c(n1)C(F)(F)F

InChI Key: InChIKey=XEQFXPQHQCSILM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50062666   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear factor NF-kappa-B (NF-kB) (Homo sapiens (Human))	BDBM50062666 (2-Amino-4-trifluoromethyl-pyrimidine-5-carboxylic ...) Show SMILES Nc1ncc(C(=O)Nc2cc(Cl)cc(Cl)c2)c(n1)C(F)(F)F Show InChI InChI=1S/C12H7Cl2F3N4O/c13-5-1-6(14)3-7(2-5)20-10(22)8-4-19-11(18)21-9(8)12(15,16)17/h1-4H,(H,20,22)(H2,18,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor				J Med Chem 41: 413-9 (1998) Article DOI: 10.1021/jm970671g BindingDB Entry DOI: 10.7270/Q2P55MMZ
					More data for this Ligand-Target Pair
Activating transcription factor 1 (Homo sapiens (Human))	BDBM50062666 (2-Amino-4-trifluoromethyl-pyrimidine-5-carboxylic ...) Show SMILES Nc1ncc(C(=O)Nc2cc(Cl)cc(Cl)c2)c(n1)C(F)(F)F Show InChI InChI=1S/C12H7Cl2F3N4O/c13-5-1-6(14)3-7(2-5)20-10(22)8-4-19-11(18)21-9(8)12(15,16)17/h1-4H,(H,20,22)(H2,18,19,21)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against human Jurkat T-Cells stably transfected with activating transcription factor 1				J Med Chem 41: 413-9 (1998) Article DOI: 10.1021/jm970671g BindingDB Entry DOI: 10.7270/Q2P55MMZ
					More data for this Ligand-Target Pair