BDBM50062675 5-{4-[5-(4-Fluoro-benzyl)-thiophen-2-yl]-but-3-ynyl}-3,4-dihydroxy-5H-furan-2-one::CHEMBL132859

SMILES: Oc1oc(CCC#Cc2ccc(Cc3ccc(F)cc3)s2)c(O)c1O

InChI Key: InChIKey=YAMAMNCYUFWOKI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50062675   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50062675 (5-{4-[5-(4-Fluoro-benzyl)-thiophen-2-yl]-but-3-yny...) Show SMILES Oc1oc(CCC#Cc2ccc(Cc3ccc(F)cc3)s2)c(O)c1O Show InChI InChI=1S/C19H15FO4S/c20-13-7-5-12(6-8-13)11-15-10-9-14(25-15)3-1-2-4-16-17(21)18(22)19(23)24-16/h5-10,21-23H,2,4,11H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
OXIS International, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against 5-lipoxygenase obtained from rat basophilic leukemia cells				J Med Chem 41: 420-7 (1998) Article DOI: 10.1021/jm970034q BindingDB Entry DOI: 10.7270/Q2JD4VW7
					More data for this Ligand-Target Pair