BDBM50063416 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone::CHEMBL368295

SMILES: Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccncc3)c3ncc(Br)cc3CCc2c1

InChI Key: InChIKey=CXHRDHMBLZINQP-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50063416   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50063416 (1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]c...) Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccncc3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C25H24BrClN4O/c26-20-14-19-2-1-18-15-21(27)3-4-22(18)25(24(19)29-16-20)31-11-9-30(10-12-31)23(32)13-17-5-7-28-8-6-17/h3-8,14-16,25H,1-2,9-13H2	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Farnesyltransferase from Ras-CVLS or Ras-CVLL in Cos-7 monkey kidney cells				J Med Chem 41: 877-93 (1998) Article DOI: 10.1021/jm970462w BindingDB Entry DOI: 10.7270/Q2M61JDN
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Rattus norvegicus (rat))	BDBM50063416 (1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]c...) Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccncc3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C25H24BrClN4O/c26-20-14-19-2-1-18-15-21(27)3-4-22(18)25(24(19)29-16-20)31-11-9-30(10-12-31)23(32)13-17-5-7-28-8-6-17/h3-8,14-16,25H,1-2,9-13H2	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of rat Geranylgeranyl transferase (GGPT)				J Med Chem 41: 877-93 (1998) Article DOI: 10.1021/jm970462w BindingDB Entry DOI: 10.7270/Q2M61JDN
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50063416 (1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]c...) Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccncc3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C25H24BrClN4O/c26-20-14-19-2-1-18-15-21(27)3-4-22(18)25(24(19)29-16-20)31-11-9-30(10-12-31)23(32)13-17-5-7-28-8-6-17/h3-8,14-16,25H,1-2,9-13H2	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogene				J Med Chem 41: 877-93 (1998) Article DOI: 10.1021/jm970462w BindingDB Entry DOI: 10.7270/Q2M61JDN
					More data for this Ligand-Target Pair