BDBM50064473 CHEMBL3401194

SMILES: Cc1cn(-c2ccc(F)cc2)c(=O)n2cc(COc3ccccc3)nc12

InChI Key: InChIKey=KKAQSQHMORWTJK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50064473   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50064473 (CHEMBL3401194) Show SMILES Cc1cn(-c2ccc(F)cc2)c(=O)n2cc(COc3ccccc3)nc12 Show InChI InChI=1S/C20H16FN3O2/c1-14-11-23(17-9-7-15(21)8-10-17)20(25)24-12-16(22-19(14)24)13-26-18-5-3-2-4-6-18/h2-12H,13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research and Development Curated by ChEMBL					Assay Description Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assay				Bioorg Med Chem Lett 25: 1310-7 (2015) Article DOI: 10.1016/j.bmcl.2015.01.038 BindingDB Entry DOI: 10.7270/Q2057HNQ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50064473 (CHEMBL3401194) Show SMILES Cc1cn(-c2ccc(F)cc2)c(=O)n2cc(COc3ccccc3)nc12 Show InChI InChI=1S/C20H16FN3O2/c1-14-11-23(17-9-7-15(21)8-10-17)20(25)24-12-16(22-19(14)24)13-26-18-5-3-2-4-6-18/h2-12H,13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research and Development Curated by ChEMBL					Assay Description Negative allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assay				Bioorg Med Chem Lett 25: 1310-7 (2015) Article DOI: 10.1016/j.bmcl.2015.01.038 BindingDB Entry DOI: 10.7270/Q2057HNQ
					More data for this Ligand-Target Pair