BDBM50064816 2-(4-tert-Butyl-2-methyl-benzyl)-4,5-dihydro-1H-imidazole::CHEMBL70409
SMILES: Cc1cc(ccc1CC1=NCCN1)C(C)(C)C
InChI Key: InChIKey=JLVBPZLGXWLQKB-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 1D (Homo sapiens (Human)) | BDBM50064816 (2-(4-tert-Butyl-2-methyl-benzyl)-4,5-dihydro-1H-im...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]-5-HT trifluoroacetate as radioligand | J Med Chem 41: 2243-51 (1998) Article DOI: 10.1021/jm970513p BindingDB Entry DOI: 10.7270/Q28K7872 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1B (Homo sapiens (Human)) | BDBM50064816 (2-(4-tert-Butyl-2-methyl-benzyl)-4,5-dihydro-1H-im...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 712 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 1B receptor using [3H]-5-HT trifluoroacetate as radioligand | J Med Chem 41: 2243-51 (1998) Article DOI: 10.1021/jm970513p BindingDB Entry DOI: 10.7270/Q28K7872 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1D (Homo sapiens (Human)) | BDBM50064816 (2-(4-tert-Butyl-2-methyl-benzyl)-4,5-dihydro-1H-im...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.67E+3 | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV) | J Med Chem 41: 2243-51 (1998) Article DOI: 10.1021/jm970513p BindingDB Entry DOI: 10.7270/Q28K7872 | |||||||||||
More data for this Ligand-Target Pair |