BDBM50066450 1-Chloro-4-(3-chloro-4-methoxy-benzylamino)-phthalazine-6-carbonitrile::CHEMBL115732::CHEMBL545242

SMILES: COc1ccc(CNc2nnc(Cl)c3ccc(cc23)C#N)cc1Cl

InChI Key: InChIKey=CMKOKNGHDDWVKW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50066450   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50066450 (1-Chloro-4-(3-chloro-4-methoxy-benzylamino)-phthal...) Show SMILES COc1ccc(CNc2nnc(Cl)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C17H12Cl2N4O/c1-24-15-5-3-11(7-14(15)18)9-21-17-13-6-10(8-20)2-4-12(13)16(19)22-23-17/h2-7H,9H2,1H3,(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Company, Ltd. Curated by ChEMBL					Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets				J Med Chem 43: 2523-9 (2000) BindingDB Entry DOI: 10.7270/Q2T72J4N
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50066450 (1-Chloro-4-(3-chloro-4-methoxy-benzylamino)-phthal...) Show SMILES COc1ccc(CNc2nnc(Cl)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C17H12Cl2N4O/c1-24-15-5-3-11(7-14(15)18)9-21-17-13-6-10(8-20)2-4-12(13)16(19)22-23-17/h2-7H,9H2,1H3,(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 5 from porcine platelets				J Med Chem 41: 3367-72 (1998) Article DOI: 10.1021/jm970815r BindingDB Entry DOI: 10.7270/Q2MS3RXG
					More data for this Ligand-Target Pair