BindingDB PrimarySearch

BDBM50067030 (1E,4Z,6E)-1,7-Bis-(3,4-dihydroxy-phenyl)-5-hydroxy-hepta-1,4,6-trien-3-one::(1E,4Z,6E)-1,7-bis(3,4-dihydroxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one::1,7-Bis-(3,4-dihydroxy-phenyl)-5-hydroxy-hepta-1,4,6-trien-3-one::1,7-bis(3,4-dihydroxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one::CHEMBL129964

SMILES: Oc1ccc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(O)c2)cc1O

InChI Key: InChIKey=OJFGQVZAISEIPG-UHFFFAOYSA-N

Data: 4 IC50 3 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50067030
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50067030 ((1E,4Z,6E)-1,7-Bis-(3,4-dihydroxy-phenyl)-5-hydrox...) Show SMILES Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Università di Roma La Sapienza Curated by ChEMBL					Assay Description Inhibition of GST-p300 HAT assessed as histone acetylation				J Med Chem 50: 1973-7 (2007) Article DOI: 10.1021/jm060943s BindingDB Entry DOI: 10.7270/Q2WM1D3K
Università di Roma La Sapienza Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50067030 ((1E,4Z,6E)-1,7-Bis-(3,4-dihydroxy-phenyl)-5-hydrox...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Roma"La Sapienza" Curated by ChEMBL					Assay Description Compound concentration required to reduce HIV-1 Integrase 3'-processing activity by 50%				J Med Chem 41: 3948-60 (1998) Article DOI: 10.1021/jm9707232 BindingDB Entry DOI: 10.7270/Q29024G3
Universit£ di Roma"La Sapienza" Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50067030 ((1E,4Z,6E)-1,7-Bis-(3,4-dihydroxy-phenyl)-5-hydrox...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	708	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Health Science Center Curated by ChEMBL					Assay Description Inhibitory activity against HIV-1 Integrase (HIV-1-IN)				J Med Chem 45: 841-52 (2002) BindingDB Entry DOI: 10.7270/Q28W3FGV
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM50067030 ((1E,4Z,6E)-1,7-Bis-(3,4-dihydroxy-phenyl)-5-hydrox...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+6	n/a	n/a	n/a	n/a	n/a	n/a
Yamagata University Curated by ChEMBL					Assay Description Inhibition of recombinant BACE1 (unknown origin)				Bioorg Med Chem Lett 24: 685-90 (2014) Article DOI: 10.1016/j.bmcl.2013.11.039 BindingDB Entry DOI: 10.7270/Q26T0QMH
Yamagata University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, epsilon (Homo sapiens (Human))	BDBM50067030 ((1E,4Z,6E)-1,7-Bis-(3,4-dihydroxy-phenyl)-5-hydrox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.11E+4	n/a	n/a	n/a	n/a
University of Houston Curated by ChEMBL					Assay Description Binding affinity to GST-tagged PKCepsilon expressed in Escherichia coli BL21(DE3) by fluorescence quenching				Bioorg Med Chem 18: 1591-8 (2010) Article DOI: 10.1016/j.bmc.2009.12.075 BindingDB Entry DOI: 10.7270/Q2KP834V
University of Houston Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM50067030 ((1E,4Z,6E)-1,7-Bis-(3,4-dihydroxy-phenyl)-5-hydrox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.57E+3	n/a	n/a	n/a	n/a
University of Houston Curated by ChEMBL					Assay Description Binding affinity to GST-tagged PKCtheta expressed in Escherichia coli BL21(DE3) by fluorescence quenching				Bioorg Med Chem 18: 1591-8 (2010) Article DOI: 10.1016/j.bmc.2009.12.075 BindingDB Entry DOI: 10.7270/Q2KP834V
University of Houston Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM50067030 ((1E,4Z,6E)-1,7-Bis-(3,4-dihydroxy-phenyl)-5-hydrox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.25E+4	n/a	n/a	n/a	n/a
University of Houston Curated by ChEMBL					Assay Description Binding affinity to GST-tagged PKCdelta expressed in Escherichia coli BL21(DE3) by fluorescence quenching				Bioorg Med Chem 18: 1591-8 (2010) Article DOI: 10.1016/j.bmc.2009.12.075 BindingDB Entry DOI: 10.7270/Q2KP834V
University of Houston Curated by ChEMBL					More data for this Ligand-Target Pair