BDBM50067671 5-[1-(2,5-Difluoro-phenyl)-meth-(Z)-ylidene]-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL137103

SMILES: CC1=CC(C)(C)Nc2ccc3-c4ccccc4O\C(=C/c4cc(F)ccc4F)c3c12

InChI Key: InChIKey=ZVALABNDJZPNNC-QRVIBDJDSA-N

Data: 3 KI  3 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50067671   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Progesterone receptor (Homo sapiens (Human))	BDBM50067671 (5-[1-(2,5-Difluoro-phenyl)-meth-(Z)-ylidene]-2,2,4...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4O\C(=C/c4cc(F)ccc4F)c3c12 |t:1| Show InChI InChI=1S/C26H21F2NO/c1-15-14-26(2,3)29-21-11-9-19-18-6-4-5-7-22(18)30-23(25(19)24(15)21)13-16-12-17(27)8-10-20(16)28/h4-14,29H,1-3H3/b23-13-	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity against human progesterone receptor				J Med Chem 41: 4354-9 (1998) Article DOI: 10.1021/jm980366a BindingDB Entry DOI: 10.7270/Q2V40TB5
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50067671 (5-[1-(2,5-Difluoro-phenyl)-meth-(Z)-ylidene]-2,2,4...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4O\C(=C/c4cc(F)ccc4F)c3c12 |t:1| Show InChI InChI=1S/C26H21F2NO/c1-15-14-26(2,3)29-21-11-9-19-18-6-4-5-7-22(18)30-23(25(19)24(15)21)13-16-12-17(27)8-10-20(16)28/h4-14,29H,1-3H3/b23-13-	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	173	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity against human glucocorticoid receptor expressed in SF-12 cells				J Med Chem 41: 4354-9 (1998) Article DOI: 10.1021/jm980366a BindingDB Entry DOI: 10.7270/Q2V40TB5
					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50067671 (5-[1-(2,5-Difluoro-phenyl)-meth-(Z)-ylidene]-2,2,4...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4O\C(=C/c4cc(F)ccc4F)c3c12 |t:1| Show InChI InChI=1S/C26H21F2NO/c1-15-14-26(2,3)29-21-11-9-19-18-6-4-5-7-22(18)30-23(25(19)24(15)21)13-16-12-17(27)8-10-20(16)28/h4-14,29H,1-3H3/b23-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	887	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity against human androgen receptor				J Med Chem 41: 4354-9 (1998) Article DOI: 10.1021/jm980366a BindingDB Entry DOI: 10.7270/Q2V40TB5
					More data for this Ligand-Target Pair
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50067671 (5-[1-(2,5-Difluoro-phenyl)-meth-(Z)-ylidene]-2,2,4...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4O\C(=C/c4cc(F)ccc4F)c3c12 |t:1| Show InChI InChI=1S/C26H21F2NO/c1-15-14-26(2,3)29-21-11-9-19-18-6-4-5-7-22(18)30-23(25(19)24(15)21)13-16-12-17(27)8-10-20(16)28/h4-14,29H,1-3H3/b23-13-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity (IC50) against human mineralocorticoid receptor expressed in CV-1 cells				J Med Chem 41: 4354-9 (1998) Article DOI: 10.1021/jm980366a BindingDB Entry DOI: 10.7270/Q2V40TB5
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50067671 (5-[1-(2,5-Difluoro-phenyl)-meth-(Z)-ylidene]-2,2,4...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4O\C(=C/c4cc(F)ccc4F)c3c12 |t:1| Show InChI InChI=1S/C26H21F2NO/c1-15-14-26(2,3)29-21-11-9-19-18-6-4-5-7-22(18)30-23(25(19)24(15)21)13-16-12-17(27)8-10-20(16)28/h4-14,29H,1-3H3/b23-13-	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	371	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity (IC50) against human glucocorticoid receptor expressed in CV-1 cells				J Med Chem 41: 4354-9 (1998) Article DOI: 10.1021/jm980366a BindingDB Entry DOI: 10.7270/Q2V40TB5
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50067671 (5-[1-(2,5-Difluoro-phenyl)-meth-(Z)-ylidene]-2,2,4...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4O\C(=C/c4cc(F)ccc4F)c3c12 |t:1| Show InChI InChI=1S/C26H21F2NO/c1-15-14-26(2,3)29-21-11-9-19-18-6-4-5-7-22(18)30-23(25(19)24(15)21)13-16-12-17(27)8-10-20(16)28/h4-14,29H,1-3H3/b23-13-	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Effective concentration (EC50) against human progesterone receptor expressed in CV-1 cell				J Med Chem 41: 4354-9 (1998) Article DOI: 10.1021/jm980366a BindingDB Entry DOI: 10.7270/Q2V40TB5
					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM50067671 (5-[1-(2,5-Difluoro-phenyl)-meth-(Z)-ylidene]-2,2,4...) Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4O\C(=C/c4cc(F)ccc4F)c3c12 |t:1| Show InChI InChI=1S/C26H21F2NO/c1-15-14-26(2,3)29-21-11-9-19-18-6-4-5-7-22(18)30-23(25(19)24(15)21)13-16-12-17(27)8-10-20(16)28/h4-14,29H,1-3H3/b23-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity (IC50) against human androgen receptor expressed in CV-1 cells				J Med Chem 41: 4354-9 (1998) Article DOI: 10.1021/jm980366a BindingDB Entry DOI: 10.7270/Q2V40TB5
					More data for this Ligand-Target Pair