BindingDB PrimarySearch

BDBM50067880 4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one::4-methoxy-7H-furo[3,2-g]chromen-7-one::5-methoxypsoralen::5-methoxypsoralene::Bergaptene::CHEMBL24171::Heraclin::Majudin

SMILES: COc1c2ccoc2cc2oc(=O)ccc12

InChI Key: InChIKey=BGEBZHIAGXMEMV-UHFFFAOYSA-N

Data: 1 KI 4 IC50 6 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50067880
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cytochrome P450 2A6 (Homo sapiens (Human))	BDBM50067880 (4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one \| 4-me...) Show SMILES COc1c2ccoc2cc2oc(=O)ccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Mechanism based inhibition of human cytochrome P450 2A6 measured by coumarin 7-hydroxylation				Curr Drug Metab 6: 413-54 (2005) BindingDB Entry DOI: 10.7270/Q2VQ33X3
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.3 (Mus musculus)	BDBM50067880 (4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one \| 4-me...) Show SMILES COc1c2ccoc2cc2oc(=O)ccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.01E+5	n/a	n/a	n/a	n/a	n/a
University of Kiel Curated by ChEMBL					Assay Description Blockade of peak Kv1.3 potassium currents				J Med Chem 41: 4542-9 (1998) Article DOI: 10.1021/jm981032o BindingDB Entry DOI: 10.7270/Q2B56HWK
University of Kiel Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50067880 (4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one \| 4-me...) Show SMILES COc1c2ccoc2cc2oc(=O)ccc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.11E+5	n/a	n/a	n/a	n/a	n/a
University of Kiel Curated by ChEMBL					Assay Description Blockade of peak K+ currents against Kv3.1 gene				J Med Chem 41: 4542-9 (1998) Article DOI: 10.1021/jm981032o BindingDB Entry DOI: 10.7270/Q2B56HWK
University of Kiel Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50067880 (4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one \| 4-me...) Show SMILES COc1c2ccoc2cc2oc(=O)ccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a
University of Kiel Curated by ChEMBL					Assay Description Blockade of peak K+ currents against Kv1.2 gene				J Med Chem 41: 4542-9 (1998) Article DOI: 10.1021/jm981032o BindingDB Entry DOI: 10.7270/Q2B56HWK
University of Kiel Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50067880 (4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one \| 4-me...) Show SMILES COc1c2ccoc2cc2oc(=O)ccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.87E+5	n/a	n/a	n/a	n/a	n/a
University of Kiel Curated by ChEMBL					Assay Description Blockade of peak K+ currents against Kv1.6 gene				J Med Chem 41: 4542-9 (1998) Article DOI: 10.1021/jm981032o BindingDB Entry DOI: 10.7270/Q2B56HWK
University of Kiel Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM50067880 (4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one \| 4-me...) Show SMILES COc1c2ccoc2cc2oc(=O)ccc12 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
R.C. Patel Institute of Pharmaceutical Education and Research Curated by ChEMBL					Assay Description Inhibition of MAO-A (unknown origin)				Bioorg Med Chem 21: 2434-50 (2013) Article DOI: 10.1016/j.bmc.2013.02.017 BindingDB Entry DOI: 10.7270/Q25T3PCS
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM50067880 (4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one \| 4-me...) Show SMILES COc1c2ccoc2cc2oc(=O)ccc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Kinki University Curated by ChEMBL					Assay Description Inhibition of recombinant human BACE1 using Rh-EVNLDAEFK as substrate after 60 mins by fluorescence quenching assay				Bioorg Med Chem 20: 784-8 (2012) Article DOI: 10.1016/j.bmc.2011.12.002 BindingDB Entry DOI: 10.7270/Q2F47PKK
Kinki University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50067880 (4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one \| 4-me...) Show SMILES COc1c2ccoc2cc2oc(=O)ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of PTP1B (unknown origin) using pNPP substrate measured after 3 mins by colorimetric assay				Bioorg Med Chem Lett 25: 2028-32 (2015) Article DOI: 10.1016/j.bmcl.2015.04.003 BindingDB Entry DOI: 10.7270/Q2XP76M3
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50067880 (4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one \| 4-me...) Show SMILES COc1c2ccoc2cc2oc(=O)ccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.01E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of Kv1.3 potassium channel expressed in mouse L929 cells by whole cell patch clamp				Eur J Med Chem 44: 1838-52 (2009) Article DOI: 10.1016/j.ejmech.2008.10.033 BindingDB Entry DOI: 10.7270/Q2QR4X5N
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50067880 (4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one \| 4-me...) Show SMILES COc1c2ccoc2cc2oc(=O)ccc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a
University of Kiel Curated by ChEMBL					Assay Description Blockade of peak K+ currents against Kv1.1 gene				J Med Chem 41: 4542-9 (1998) Article DOI: 10.1021/jm981032o BindingDB Entry DOI: 10.7270/Q2B56HWK
University of Kiel Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5 (Homo sapiens (Human))	BDBM50067880 (4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one \| 4-me...) Show SMILES COc1c2ccoc2cc2oc(=O)ccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.77E+5	n/a	n/a	n/a	n/a	n/a
University of Kiel Curated by ChEMBL					Assay Description Blockade of peak K+ currents against Kv1.5 gene				J Med Chem 41: 4542-9 (1998) Article DOI: 10.1021/jm981032o BindingDB Entry DOI: 10.7270/Q2B56HWK
University of Kiel Curated by ChEMBL					More data for this Ligand-Target Pair