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TargetTyrosine-protein phosphatase non-receptor type 1
LigandBDBM50067880
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1466859 (CHEMBL3405965)
IC50 11700±n/a nM
Citation Li, JL; Gao, LX; Meng, FW; Tang, CL; Zhang, RJ; Li, JY; Luo, C; Li, J; Zhao, WM PTP1B inhibitors from stems of Angelica keiskei (Ashitaba). Bioorg Med Chem Lett25:2028-32 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein phosphatase non-receptor type 1
Name:Tyrosine-protein phosphatase non-receptor type 1
Synonyms:PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:Protein phosphatase
Mol. Mass.:49963.76
Organism:Homo sapiens (Human)
Description:Human recombinant GST-fusion PTP1B (1-435).
Residue:435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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  Blast E-value cutoff:
BDBM50067880
n/a
NameBDBM50067880
Synonyms:4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one | 4-methoxy-7H-furo[3,2-g]chromen-7-one | 5-methoxypsoralen | 5-methoxypsoralene | Bergaptene | CHEMBL24171 | Heraclin | Majudin
TypeSmall organic molecule
Emp. Form.C12H8O4
Mol. Mass.216.1895
SMILESCOc1c2ccoc2cc2oc(=O)ccc12
Structure
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