BDBM50068482 (2R,3R,5R)-8-Methyl-2-propyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane::CHEMBL148419

SMILES: CCC[C@H]1C2CC[C@H](C[C@H]1c1ccc(C)cc1)N2C

InChI Key: InChIKey=QCRUGFCHRLZVTK-HRBLRVMOSA-N

Data: 3 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50068482   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50068482 ((2R,3R,5R)-8-Methyl-2-propyl-3-p-tolyl-8-aza-bicyc...) Show SMILES CCC[C@H]1C2CC[C@H](C[C@H]1c1ccc(C)cc1)N2C |TLB:18:17:9.3.8:5.6,THB:2:3:17:5.6| Show InChI InChI=1S/C18H27N/c1-4-5-16-17(14-8-6-13(2)7-9-14)12-15-10-11-18(16)19(15)3/h6-9,15-18H,4-5,10-12H2,1-3H3/t15-,16-,17+,18?/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Binding affinity of compound on dopamine transporters of rat striated membranes using [3H]- mazindol.				J Med Chem 41: 4973-82 (1999) Article DOI: 10.1021/jm9802564 BindingDB Entry DOI: 10.7270/Q29S1RQ7
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50068482 ((2R,3R,5R)-8-Methyl-2-propyl-3-p-tolyl-8-aza-bicyc...) Show SMILES CCC[C@H]1C2CC[C@H](C[C@H]1c1ccc(C)cc1)N2C |TLB:18:17:9.3.8:5.6,THB:2:3:17:5.6| Show InChI InChI=1S/C18H27N/c1-4-5-16-17(14-8-6-13(2)7-9-14)12-15-10-11-18(16)19(15)3/h6-9,15-18H,4-5,10-12H2,1-3H3/t15-,16-,17+,18?/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Binding affinity for [3H]DA (Dopamine transporter) uptake by striated synaptosomes				J Med Chem 41: 4973-82 (1999) Article DOI: 10.1021/jm9802564 BindingDB Entry DOI: 10.7270/Q29S1RQ7
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50068482 ((2R,3R,5R)-8-Methyl-2-propyl-3-p-tolyl-8-aza-bicyc...) Show SMILES CCC[C@H]1C2CC[C@H](C[C@H]1c1ccc(C)cc1)N2C |TLB:18:17:9.3.8:5.6,THB:2:3:17:5.6| Show InChI InChI=1S/C18H27N/c1-4-5-16-17(14-8-6-13(2)7-9-14)12-15-10-11-18(16)19(15)3/h6-9,15-18H,4-5,10-12H2,1-3H3/t15-,16-,17+,18?/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Binding affinity for Serotonin transporter was determined by [3H]5-HT (serotonin) uptake by striated synaptosomes				J Med Chem 41: 4973-82 (1999) Article DOI: 10.1021/jm9802564 BindingDB Entry DOI: 10.7270/Q29S1RQ7
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50068482 ((2R,3R,5R)-8-Methyl-2-propyl-3-p-tolyl-8-aza-bicyc...) Show SMILES CCC[C@H]1C2CC[C@H](C[C@H]1c1ccc(C)cc1)N2C |TLB:18:17:9.3.8:5.6,THB:2:3:17:5.6| Show InChI InChI=1S/C18H27N/c1-4-5-16-17(14-8-6-13(2)7-9-14)12-15-10-11-18(16)19(15)3/h6-9,15-18H,4-5,10-12H2,1-3H3/t15-,16-,17+,18?/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Inhibitory activity determined for [3H]DA (Dopamine transporter) uptake by striated synaptosomes				J Med Chem 41: 4973-82 (1999) Article DOI: 10.1021/jm9802564 BindingDB Entry DOI: 10.7270/Q29S1RQ7
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50068482 ((2R,3R,5R)-8-Methyl-2-propyl-3-p-tolyl-8-aza-bicyc...) Show SMILES CCC[C@H]1C2CC[C@H](C[C@H]1c1ccc(C)cc1)N2C |TLB:18:17:9.3.8:5.6,THB:2:3:17:5.6| Show InChI InChI=1S/C18H27N/c1-4-5-16-17(14-8-6-13(2)7-9-14)12-15-10-11-18(16)19(15)3/h6-9,15-18H,4-5,10-12H2,1-3H3/t15-,16-,17+,18?/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Inhibitory activity on dopamine transporters of rat striated membranes using [3H]- mazindol.				J Med Chem 41: 4973-82 (1999) Article DOI: 10.1021/jm9802564 BindingDB Entry DOI: 10.7270/Q29S1RQ7
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50068482 ((2R,3R,5R)-8-Methyl-2-propyl-3-p-tolyl-8-aza-bicyc...) Show SMILES CCC[C@H]1C2CC[C@H](C[C@H]1c1ccc(C)cc1)N2C |TLB:18:17:9.3.8:5.6,THB:2:3:17:5.6| Show InChI InChI=1S/C18H27N/c1-4-5-16-17(14-8-6-13(2)7-9-14)12-15-10-11-18(16)19(15)3/h6-9,15-18H,4-5,10-12H2,1-3H3/t15-,16-,17+,18?/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Inhibitory activity against Serotonin transporter was determined for [3H]5-HT (serotonin) uptake by striated synaptosomes				J Med Chem 41: 4973-82 (1999) Article DOI: 10.1021/jm9802564 BindingDB Entry DOI: 10.7270/Q29S1RQ7
					More data for this Ligand-Target Pair