BDBM50068745 CHEMBL78499::N-(3,4-Dimethyl-isoxazol-5-yl)-2-fluoro-benzenesulfonamide

SMILES: Cc1noc(NS(=O)(=O)c2ccccc2F)c1C

InChI Key: InChIKey=RZRSCFPIKIODFH-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50068745   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
EDNRA (RAT)	BDBM50068745 (CHEMBL78499 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-flu...) Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2F)c1C Show InChI InChI=1S/C11H11FN2O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-6-4-3-5-9(10)12/h3-6,14H,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor				J Med Chem 41: 5198-218 (1999) Article DOI: 10.1021/jm970872k BindingDB Entry DOI: 10.7270/Q2J9672R
					More data for this Ligand-Target Pair
Endothelin-1 receptor (Homo sapiens (Human))	BDBM50068745 (CHEMBL78499 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-flu...) Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2F)c1C Show InChI InChI=1S/C11H11FN2O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-6-4-3-5-9(10)12/h3-6,14H,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation				Bioorg Med Chem Lett 6: 2393-2398 (1996) Article DOI: 10.1016/0960-894X(96)00441-6 BindingDB Entry DOI: 10.7270/Q22V2G3R
					More data for this Ligand-Target Pair