BDBM50068806 CHEMBL3402386

SMILES: OCCOc1cccc(Nc2nc(Nc3cccc(O)c3)ncc2F)c1

InChI Key: InChIKey=YUERHWLKMBYTQY-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50068806   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50068806 (CHEMBL3402386) Show SMILES OCCOc1cccc(Nc2nc(Nc3cccc(O)c3)ncc2F)c1 Show InChI InChI=1S/C18H17FN4O3/c19-16-11-20-18(22-12-3-1-5-14(25)9-12)23-17(16)21-13-4-2-6-15(10-13)26-8-7-24/h1-6,9-11,24-25H,7-8H2,(H2,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	670	n/a	n/a	n/a	n/a
Amarit Bioscience, Inc. Curated by ChEMBL					Assay Description Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay				Bioorg Med Chem Lett 25: 2117-21 (2015) Article DOI: 10.1016/j.bmcl.2015.03.075 BindingDB Entry DOI: 10.7270/Q2R49SFK
					More data for this Ligand-Target Pair