null
SMILES: Cc1cccc(c1)C1Nc2cccc3cccc(N1)c23
InChI Key: InChIKey=HPFJVSRZYNTHHT-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine protease hepsin (Homo sapiens (Human)) | BDBM50069104 (CHEMBL1449583 | US9182402, 4) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center US Patent | Assay Description To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav... | US Patent US9182402 (2015) BindingDB Entry DOI: 10.7270/Q23F4NF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease hepsin (Homo sapiens (Human)) | BDBM50069104 (CHEMBL1449583 | US9182402, 4) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of hepsin (unknown origin) | Bioorg Med Chem 23: 2328-43 (2015) Article DOI: 10.1016/j.bmc.2015.03.072 BindingDB Entry DOI: 10.7270/Q23F4RB4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Bos taurus (Bovine)) | BDBM50069104 (CHEMBL1449583 | US9182402, 4) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center US Patent | Assay Description To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav... | US Patent US9182402 (2015) BindingDB Entry DOI: 10.7270/Q23F4NF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trypsin (Sus scrofa) | BDBM50069104 (CHEMBL1449583 | US9182402, 4) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fred Hutchinson Cancer Research Center US Patent | Assay Description To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav... | US Patent US9182402 (2015) BindingDB Entry DOI: 10.7270/Q23F4NF7 | |||||||||||
More data for this Ligand-Target Pair |