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BDBM50069252 3-Benzhydrylidene-1-{2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethyl}-pyrrolidine-2,5-dione::CHEMBL144158
SMILES: Fc1ccc(cc1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
InChI Key: InChIKey=SLHOTSULTKLUPX-UHFFFAOYSA-N
Data: 5 KI
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50069252 (3-Benzhydrylidene-1-{2-[4-(4-fluoro-phenyl)-pipera...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet  | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 529 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense Curated by ChEMBL | Assay Description In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand | Bioorg Med Chem Lett 8: 581-6 (1999) BindingDB Entry DOI: 10.7270/Q2N878XB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50069252 (3-Benzhydrylidene-1-{2-[4-(4-fluoro-phenyl)-pipera...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense Curated by ChEMBL | Assay Description Binding affinity at 5-hydroxytryptamine 1A (5-HT1A) receptor in rat cerebral cortex using [3H]-8-OH-DPAT as radioligand | J Med Chem 42: 36-49 (1999) Article DOI: 10.1021/jm980285e BindingDB Entry DOI: 10.7270/Q2B27TFT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50069252 (3-Benzhydrylidene-1-{2-[4-(4-fluoro-phenyl)-pipera...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense Curated by ChEMBL | Assay Description In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand | Bioorg Med Chem Lett 8: 581-6 (1999) BindingDB Entry DOI: 10.7270/Q2N878XB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50069252 (3-Benzhydrylidene-1-{2-[4-(4-fluoro-phenyl)-pipera...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense Curated by ChEMBL | Assay Description In vitro binding affinity towards Dopamine receptor D2 of rat striatal membranes using [3H]- raclopride | J Med Chem 42: 36-49 (1999) Article DOI: 10.1021/jm980285e BindingDB Entry DOI: 10.7270/Q2B27TFT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50069252 (3-Benzhydrylidene-1-{2-[4-(4-fluoro-phenyl)-pipera...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense Curated by ChEMBL | Assay Description In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand | Bioorg Med Chem Lett 8: 581-6 (1999) BindingDB Entry DOI: 10.7270/Q2N878XB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
