BDBM50069261 3-Benzhydrylidene-1-[4-(4-phenyl-piperazin-1-yl)-butyl]-pyrrolidine-2,5-dione::CHEMBL342995::cid_9511286

SMILES: O=[#6]-1-[#6]\[#6](=[#6](/c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1

InChI Key: InChIKey=QFESFPVBIJPECI-UHFFFAOYSA-N

Data: 5 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50069261   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50069261 (3-Benzhydrylidene-1-[4-(4-phenyl-piperazin-1-yl)-b...) Show SMILES O=[#6]-1-[#6]\[#6](=[#6](/c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1 Show InChI InChI=1S/C31H33N3O2/c35-29-24-28(30(25-12-4-1-5-13-25)26-14-6-2-7-15-26)31(36)34(29)19-11-10-18-32-20-22-33(23-21-32)27-16-8-3-9-17-27/h1-9,12-17H,10-11,18-24H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Complutense Curated by ChEMBL					Assay Description In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand				Bioorg Med Chem Lett 8: 581-6 (1999) BindingDB Entry DOI: 10.7270/Q2N878XB
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50069261 (3-Benzhydrylidene-1-[4-(4-phenyl-piperazin-1-yl)-b...) Show SMILES O=[#6]-1-[#6]\[#6](=[#6](/c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1 Show InChI InChI=1S/C31H33N3O2/c35-29-24-28(30(25-12-4-1-5-13-25)26-14-6-2-7-15-26)31(36)34(29)19-11-10-18-32-20-22-33(23-21-32)27-16-8-3-9-17-27/h1-9,12-17H,10-11,18-24H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	125	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Complutense Curated by ChEMBL					Assay Description In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand				Bioorg Med Chem Lett 8: 581-6 (1999) BindingDB Entry DOI: 10.7270/Q2N878XB
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50069261 (3-Benzhydrylidene-1-[4-(4-phenyl-piperazin-1-yl)-b...) Show SMILES O=[#6]-1-[#6]\[#6](=[#6](/c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1 Show InChI InChI=1S/C31H33N3O2/c35-29-24-28(30(25-12-4-1-5-13-25)26-14-6-2-7-15-26)31(36)34(29)19-11-10-18-32-20-22-33(23-21-32)27-16-8-3-9-17-27/h1-9,12-17H,10-11,18-24H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	125	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Complutense Curated by ChEMBL					Assay Description Binding affinity at 5-hydroxytryptamine 1A (5-HT1A) receptor in rat cerebral cortex using [3H]-8-OH-DPAT as radioligand				J Med Chem 42: 36-49 (1999) Article DOI: 10.1021/jm980285e BindingDB Entry DOI: 10.7270/Q2B27TFT
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50069261 (3-Benzhydrylidene-1-[4-(4-phenyl-piperazin-1-yl)-b...) Show SMILES O=[#6]-1-[#6]\[#6](=[#6](/c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1 Show InChI InChI=1S/C31H33N3O2/c35-29-24-28(30(25-12-4-1-5-13-25)26-14-6-2-7-15-26)31(36)34(29)19-11-10-18-32-20-22-33(23-21-32)27-16-8-3-9-17-27/h1-9,12-17H,10-11,18-24H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Complutense Curated by ChEMBL					Assay Description In vitro binding affinity towards Dopamine receptor D2 of rat striatal membranes using [3H]- raclopride				J Med Chem 42: 36-49 (1999) Article DOI: 10.1021/jm980285e BindingDB Entry DOI: 10.7270/Q2B27TFT
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50069261 (3-Benzhydrylidene-1-[4-(4-phenyl-piperazin-1-yl)-b...) Show SMILES O=[#6]-1-[#6]\[#6](=[#6](/c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1 Show InChI InChI=1S/C31H33N3O2/c35-29-24-28(30(25-12-4-1-5-13-25)26-14-6-2-7-15-26)31(36)34(29)19-11-10-18-32-20-22-33(23-21-32)27-16-8-3-9-17-27/h1-9,12-17H,10-11,18-24H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Complutense Curated by ChEMBL					Assay Description In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand				Bioorg Med Chem Lett 8: 581-6 (1999) BindingDB Entry DOI: 10.7270/Q2N878XB
					More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H (Homo sapiens (Human))	BDBM50069261 (3-Benzhydrylidene-1-[4-(4-phenyl-piperazin-1-yl)-b...) Show SMILES O=[#6]-1-[#6]\[#6](=[#6](/c2ccccc2)-c2ccccc2)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1ccccc1 Show InChI InChI=1S/C31H33N3O2/c35-29-24-28(30(25-12-4-1-5-13-25)26-14-6-2-7-15-26)31(36)34(29)19-11-10-18-32-20-22-33(23-21-32)27-16-8-3-9-17-27/h1-9,12-17H,10-11,18-24H2	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	3.77E+3	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assay Provider: Xinmin Xie Assay Provider Affiliation: Bioscience Division, SRI International, Menlo Park, CA Grant Title: HTS Assay for Cav3 T-Type ...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2B856KG
					More data for this Ligand-Target Pair