BDBM50069317 CHEMBL3403548

SMILES: CNc1cc(ncn1)-c1cc(C(N)=O)n(c1)-c1cc(ccc1Cl)C(F)(F)F

InChI Key: InChIKey=AMZBOSKSWODSEE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50069317   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50069317 (CHEMBL3403548) Show SMILES CNc1cc(ncn1)-c1cc(C(N)=O)n(c1)-c1cc(ccc1Cl)C(F)(F)F Show InChI InChI=1S/C17H13ClF3N5O/c1-23-15-6-12(24-8-25-15)9-4-14(16(22)27)26(7-9)13-5-10(17(19,20)21)2-3-11(13)18/h2-8H,1H3,(H2,22,27)(H,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	331	n/a	n/a	n/a	n/a	n/a	n/a
Nerviano Medical Sciences S.r.l. Curated by ChEMBL					Assay Description Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...				Bioorg Med Chem 23: 2387-407 (2015) Article DOI: 10.1016/j.bmc.2015.03.059 BindingDB Entry DOI: 10.7270/Q2Q52RB6
					More data for this Ligand-Target Pair