BDBM50069452 (1R,2R)-3-Dimethylamino-2-phenyl-1-(2,4,6-trimethyl-phenyl)-propan-1-ol; hydrochloride::CHEMBL544633
SMILES: CN(C)C[C@H]([C@@H](O)c1c(C)cc(C)cc1C)c1ccccc1
InChI Key: InChIKey=MFIILNOEWGXKGG-AZUAARDMSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50069452 ((1R,2R)-3-Dimethylamino-2-phenyl-1-(2,4,6-trimethy...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology Curated by ChEMBL | Assay Description Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomes | Bioorg Med Chem Lett 8: 487-92 (1999) BindingDB Entry DOI: 10.7270/Q2F76D26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50069452 ((1R,2R)-3-Dimethylamino-2-phenyl-1-(2,4,6-trimethy...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 4.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology Curated by ChEMBL | Assay Description Inhibition of [3H]- DA reuptake into rat striatal synaptosomes | Bioorg Med Chem Lett 8: 487-92 (1999) BindingDB Entry DOI: 10.7270/Q2F76D26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Norepinephrine Monoamine transporters (Rattus norvegicus) | BDBM50069452 ((1R,2R)-3-Dimethylamino-2-phenyl-1-(2,4,6-trimethy...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology Curated by ChEMBL | Assay Description Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomes | Bioorg Med Chem Lett 8: 487-92 (1999) BindingDB Entry DOI: 10.7270/Q2F76D26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50069452 ((1R,2R)-3-Dimethylamino-2-phenyl-1-(2,4,6-trimethy...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 4.20E+4 | n/a | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology Curated by ChEMBL | Assay Description Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDAT | Bioorg Med Chem Lett 8: 487-92 (1999) BindingDB Entry DOI: 10.7270/Q2F76D26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50069452 ((1R,2R)-3-Dimethylamino-2-phenyl-1-(2,4,6-trimethy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology Curated by ChEMBL | Assay Description Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter-hSERT | Bioorg Med Chem Lett 8: 487-92 (1999) BindingDB Entry DOI: 10.7270/Q2F76D26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50069452 ((1R,2R)-3-Dimethylamino-2-phenyl-1-(2,4,6-trimethy...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 3.58E+4 | n/a | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology Curated by ChEMBL | Assay Description Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporter | Bioorg Med Chem Lett 8: 487-92 (1999) BindingDB Entry DOI: 10.7270/Q2F76D26 | |||||||||||
More data for this Ligand-Target Pair |