BDBM50069907 1-benzyl-4-(3-hydroxyphenyl)piperazine::3-(4-Benzyl-piperazin-1-yl)-phenol::CHEMBL88365
SMILES: Oc1cccc(c1)N1CCN(Cc2ccccc2)CC1
InChI Key: InChIKey=BISVFNHMXVNVMG-UHFFFAOYSA-N
Data: 19 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NeuroSearch Sweden AB Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cells | J Med Chem 53: 2510-20 (2010) Article DOI: 10.1021/jm901689v BindingDB Entry DOI: 10.7270/Q2NG4RKK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes | Bioorg Med Chem Lett 8: 295-300 (1999) BindingDB Entry DOI: 10.7270/Q28W3CG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]quinpirole from high affinity agonist binding site of D2 receptor in Rattus norvegicus (rat) striatal membrane | Citation and Details Article DOI: 10.1007/s00044-012-0055-5 BindingDB Entry DOI: 10.7270/Q2959MG8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratory Curated by ChEMBL | Assay Description Affinity for Dopamine receptor D2 in rat striatal membranes for high agonist state using [3H]-quinpirole | Bioorg Med Chem Lett 8: 2675-80 (1999) BindingDB Entry DOI: 10.7270/Q2C53K0X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to Homo sapiens (human) dopamine D3 receptor | Citation and Details Article DOI: 10.1007/s00044-012-0055-5 BindingDB Entry DOI: 10.7270/Q2959MG8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand | Bioorg Med Chem Lett 8: 295-300 (1999) BindingDB Entry DOI: 10.7270/Q28W3CG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratory Curated by ChEMBL | Assay Description Affinity towards human Dopamine receptor D3 expressed in CHO cells using [3H]-spiperone | Bioorg Med Chem Lett 8: 2675-80 (1999) BindingDB Entry DOI: 10.7270/Q2C53K0X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratory Curated by ChEMBL | Assay Description Affinity of compound for the Dopamine receptor D2 in rat striatal membranes was determined for low antagonist state in rat striatal membranes using [... | Bioorg Med Chem Lett 8: 2675-80 (1999) BindingDB Entry DOI: 10.7270/Q2C53K0X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes | Bioorg Med Chem Lett 8: 295-300 (1999) BindingDB Entry DOI: 10.7270/Q28W3CG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]spiperone from low affinity antagonist binding site of D2 receptor in Rattus norvegicus (rat) striatal membrane | Citation and Details Article DOI: 10.1007/s00044-012-0055-5 BindingDB Entry DOI: 10.7270/Q2959MG8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 115 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NeuroSearch Sweden AB Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from human dopamine D2 receptor at low affinity state expressed in HEK293 cells | J Med Chem 53: 2510-20 (2010) Article DOI: 10.1021/jm901689v BindingDB Entry DOI: 10.7270/Q2NG4RKK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 246 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratory Curated by ChEMBL | Assay Description Affinity towards human Dopamine receptor D2 expressed in CHO cells using [3H]-spiperone | Bioorg Med Chem Lett 8: 2675-80 (1999) BindingDB Entry DOI: 10.7270/Q2C53K0X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 246 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to Homo sapiens (human) dopamine D2S receptor | Citation and Details Article DOI: 10.1007/s00044-012-0055-5 BindingDB Entry DOI: 10.7270/Q2959MG8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 246 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone | Bioorg Med Chem Lett 8: 295-300 (1999) BindingDB Entry DOI: 10.7270/Q28W3CG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | >400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to Homo sapiens (human) dopamine D4.4 receptor | Citation and Details Article DOI: 10.1007/s00044-012-0055-5 BindingDB Entry DOI: 10.7270/Q2959MG8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratory Curated by ChEMBL | Assay Description Affinity towards human Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone | Bioorg Med Chem Lett 8: 2675-80 (1999) BindingDB Entry DOI: 10.7270/Q2C53K0X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human cloned Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone as radioligand | Bioorg Med Chem Lett 8: 295-300 (1999) BindingDB Entry DOI: 10.7270/Q28W3CG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (5HT1A) (Mus musculus (Mouse)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Binding affinity for 5-hydroxytryptamine 1A receptor | Bioorg Med Chem Lett 8: 295-300 (1999) BindingDB Entry DOI: 10.7270/Q28W3CG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor alpha-1 (Homo sapiens (Human)) | BDBM50069907 (1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...) | MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes | Bioorg Med Chem Lett 8: 295-300 (1999) BindingDB Entry DOI: 10.7270/Q28W3CG1 | |||||||||||
More data for this Ligand-Target Pair |