BDBM50070187 1-Acetyl-3-((6aR,9S,10aR)-3-tert-butyl-7-methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-9-ylmethyl)-thiourea::CHEMBL14020
SMILES: CN1C[C@H](CNC(=S)NC(C)=O)C[C@H]2[C@H]1Cc1c[nH]c3c(ccc2c13)C(C)(C)C
InChI Key: InChIKey=KUUURIADAZPOIK-POZUXBRTSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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D(1A) dopamine receptor (RAT) | BDBM50070187 (1-Acetyl-3-((6aR,9S,10aR)-3-tert-butyl-7-methyl-4,...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia & Upjohn S.p.A.-CNS Research Curated by ChEMBL | Assay Description Displacement of [3H]-SCH-23,390 from D1 receptor in rat striatum | Bioorg Med Chem Lett 8: 1117-22 (1999) BindingDB Entry DOI: 10.7270/Q2M61JF3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50070187 (1-Acetyl-3-((6aR,9S,10aR)-3-tert-butyl-7-methyl-4,...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 930 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia & Upjohn S.p.A.-CNS Research Curated by ChEMBL | Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampus | Bioorg Med Chem Lett 8: 1117-22 (1999) BindingDB Entry DOI: 10.7270/Q2M61JF3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50070187 (1-Acetyl-3-((6aR,9S,10aR)-3-tert-butyl-7-methyl-4,...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia & Upjohn S.p.A.-CNS Research Curated by ChEMBL | Assay Description Displacement of [3H]yohimbine from Alpha-2 adrenergic receptor in rat frontal cortex | Bioorg Med Chem Lett 8: 1117-22 (1999) BindingDB Entry DOI: 10.7270/Q2M61JF3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50070187 (1-Acetyl-3-((6aR,9S,10aR)-3-tert-butyl-7-methyl-4,...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia & Upjohn S.p.A.-CNS Research Curated by ChEMBL | Assay Description Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in rat frontal cortex | Bioorg Med Chem Lett 8: 1117-22 (1999) BindingDB Entry DOI: 10.7270/Q2M61JF3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50070187 (1-Acetyl-3-((6aR,9S,10aR)-3-tert-butyl-7-methyl-4,...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia & Upjohn S.p.A.-CNS Research Curated by ChEMBL | Assay Description Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat pre frontal cortex | Bioorg Med Chem Lett 8: 1117-22 (1999) BindingDB Entry DOI: 10.7270/Q2M61JF3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50070187 (1-Acetyl-3-((6aR,9S,10aR)-3-tert-butyl-7-methyl-4,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia & Upjohn S.p.A.-CNS Research Curated by ChEMBL | Assay Description Displacement of [3H]-spiroperidol from D2 receptor in rat striatum | Bioorg Med Chem Lett 8: 1117-22 (1999) BindingDB Entry DOI: 10.7270/Q2M61JF3 | |||||||||||
More data for this Ligand-Target Pair |