BDBM50070688 CHEMBL2372658::CHEMBL295578::Nazumamide A (NAZA) analogue

SMILES: CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC)NC(=O)c1cc(O)ccc1O)C(=O)N[C@@H](CC)C(O)=O

InChI Key: InChIKey=NJIPEWZPMMYJQQ-JHUFSLPMSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50070688   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prothrombin (Homo sapiens (Human))	BDBM50070688 (CHEMBL2372658 | Nazumamide A (NAZA) analogue) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC)NC(=O)c1cc(O)ccc1O)C(=O)N[C@@H](CC)C(O)=O Show InChI InChI=1S/C26H38N4O8/c1-5-14(4)21(24(35)28-18(7-3)26(37)38)29-23(34)19-9-8-12-30(19)25(36)17(6-2)27-22(33)16-13-15(31)10-11-20(16)32/h10-11,13-14,17-19,21,31-32H,5-9,12H2,1-4H3,(H,27,33)(H,28,35)(H,29,34)(H,37,38)/t14?,17?,18?,19-,21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.87E+6	n/a	n/a	n/a	n/a	8.3	n/a
Central Drug Research Institute Curated by ChEMBL					Assay Description Anti-thrombin activity by competitive enzyme assay using the fluorogenic substrate Tos-Gly-Pro-Arg-AMC at pH 8.3.				Bioorg Med Chem Lett 8: 1669-72 (1999) BindingDB Entry DOI: 10.7270/Q2G73CV8
					More data for this Ligand-Target Pair