BindingDB logo
myBDB logout

BDBM50070748 CHEMBL2372681::CHEMBL45144::Nazumamide A (NAZA) analogue

SMILES: CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](C)NC(=O)c1cc(O)ccc1O)C(=O)N[C@@H](CC)C(O)=O

InChI Key: InChIKey=JWINVMQHUBGOEK-QUMSLDQLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50070748   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prothrombin


(Homo sapiens (Human))		BDBM50070748
PNG
(CHEMBL2372681 | Nazumamide A (NAZA) analogue)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](C)NC(=O)c1cc(O)ccc1O)C(=O)N[C@@H](CC)C(O)=O
Show InChI InChI=1S/C25H36N4O8/c1-5-13(3)20(23(34)27-17(6-2)25(36)37)28-22(33)18-8-7-11-29(18)24(35)14(4)26-21(32)16-12-15(30)9-10-19(16)31/h9-10,12-14,17-18,20,30-31H,5-8,11H2,1-4H3,(H,26,32)(H,27,34)(H,28,33)(H,36,37)/t13?,14-,17?,18-,20-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.96E+6n/an/an/an/a8.3n/a



Central Drug Research Institute

Curated by ChEMBL


Assay Description
Anti-thrombin activity by competitive enzyme assay using the fluorogenic substrate Tos-Gly-Pro-Arg-AMC at pH 8.3.

Bioorg Med Chem Lett 8: 1669-72 (1999)


BindingDB Entry DOI: 10.7270/Q2G73CV8
More data for this
Ligand-Target Pair