BDBM50071019 CHEMBL3409735

SMILES: CCOC(=O)C1CCCN(C1)c1nc2CCCc2c(Nc2cc([nH]n2)C(C)(C)C)n1

InChI Key: InChIKey=RHEIFZOJVKPGAQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50071019   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50071019 (CHEMBL3409735) Show SMILES CCOC(=O)C1CCCN(C1)c1nc2CCCc2c(Nc2cc([nH]n2)C(C)(C)C)n1 Show InChI InChI=1S/C22H32N6O2/c1-5-30-20(29)14-8-7-11-28(13-14)21-23-16-10-6-9-15(16)19(25-21)24-18-12-17(26-27-18)22(2,3)4/h12,14H,5-11,13H2,1-4H3,(H2,23,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair