BDBM50071167 (2R,4R)-4-Amino-1-(2,6-dichloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid::CHEMBL60164

SMILES: N[C@@]1(C[C@@H](N(Cc2c(Cl)cccc2Cl)C1)C(O)=O)C(O)=O

InChI Key: InChIKey=XYCDYOGCZKBXGO-ZWNOBZJWSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50071167   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50071167 ((2R,4R)-4-Amino-1-(2,6-dichloro-benzyl)-pyrrolidin...) Show SMILES N[C@@]1(C[C@@H](N(Cc2c(Cl)cccc2Cl)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H14Cl2N2O4/c14-8-2-1-3-9(15)7(8)5-17-6-13(16,12(20)21)4-10(17)11(18)19/h1-3,10H,4-6,16H2,(H,18,19)(H,20,21)/t10-,13-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant Metabotropic glutamate receptor 5 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50071167 ((2R,4R)-4-Amino-1-(2,6-dichloro-benzyl)-pyrrolidin...) Show SMILES N[C@@]1(C[C@@H](N(Cc2c(Cl)cccc2Cl)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H14Cl2N2O4/c14-8-2-1-3-9(15)7(8)5-17-6-13(16,12(20)21)4-10(17)11(18)19/h1-3,10H,4-6,16H2,(H,18,19)(H,20,21)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM50071167 ((2R,4R)-4-Amino-1-(2,6-dichloro-benzyl)-pyrrolidin...) Show SMILES N[C@@]1(C[C@@H](N(Cc2c(Cl)cccc2Cl)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H14Cl2N2O4/c14-8-2-1-3-9(15)7(8)5-17-6-13(16,12(20)21)4-10(17)11(18)19/h1-3,10H,4-6,16H2,(H,18,19)(H,20,21)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 4 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50071167 ((2R,4R)-4-Amino-1-(2,6-dichloro-benzyl)-pyrrolidin...) Show SMILES N[C@@]1(C[C@@H](N(Cc2c(Cl)cccc2Cl)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H14Cl2N2O4/c14-8-2-1-3-9(15)7(8)5-17-6-13(16,12(20)21)4-10(17)11(18)19/h1-3,10H,4-6,16H2,(H,18,19)(H,20,21)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 2 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50071167 ((2R,4R)-4-Amino-1-(2,6-dichloro-benzyl)-pyrrolidin...) Show SMILES N[C@@]1(C[C@@H](N(Cc2c(Cl)cccc2Cl)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H14Cl2N2O4/c14-8-2-1-3-9(15)7(8)5-17-6-13(16,12(20)21)4-10(17)11(18)19/h1-3,10H,4-6,16H2,(H,18,19)(H,20,21)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.39E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 1 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair
GRM8 (Homo sapiens (Human))	BDBM50071167 ((2R,4R)-4-Amino-1-(2,6-dichloro-benzyl)-pyrrolidin...) Show SMILES N[C@@]1(C[C@@H](N(Cc2c(Cl)cccc2Cl)C1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H14Cl2N2O4/c14-8-2-1-3-9(15)7(8)5-17-6-13(16,12(20)21)4-10(17)11(18)19/h1-3,10H,4-6,16H2,(H,18,19)(H,20,21)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.				Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D
					More data for this Ligand-Target Pair