BDBM50073028 8-Chloro-6-methyl-2-[2-(4-phenyl-piperazin-1-yl)-ethylamino]-6H-1,6,7,9a-tetraaza-fluoren-5-one::CHEMBL51074
SMILES: Cn1nc(Cl)c2cn3nc(NCCN4CCN(CC4)c4ccccc4)ccc3c2c1=O
InChI Key: InChIKey=NZTHPWQOSONJAR-UHFFFAOYSA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50073028 (8-Chloro-6-methyl-2-[2-(4-phenyl-piperazin-1-yl)-e...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.93 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Milano Curated by ChEMBL | Assay Description The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1A adrenergic receptor expressed in CHO cells | J Med Chem 42: 173-7 (1999) Article DOI: 10.1021/jm981006q BindingDB Entry DOI: 10.7270/Q22J6B05 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1D adrenergic receptor (Homo sapiens (Human)) | BDBM50073028 (8-Chloro-6-methyl-2-[2-(4-phenyl-piperazin-1-yl)-e...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Milano Curated by ChEMBL | Assay Description The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells | J Med Chem 42: 173-7 (1999) Article DOI: 10.1021/jm981006q BindingDB Entry DOI: 10.7270/Q22J6B05 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic alpha1B (Homo sapiens (Human)) | BDBM50073028 (8-Chloro-6-methyl-2-[2-(4-phenyl-piperazin-1-yl)-e...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 15.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Milano Curated by ChEMBL | Assay Description The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1B adrenergic receptor in CHO cells | J Med Chem 42: 173-7 (1999) Article DOI: 10.1021/jm981006q BindingDB Entry DOI: 10.7270/Q22J6B05 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50073028 (8-Chloro-6-methyl-2-[2-(4-phenyl-piperazin-1-yl)-e...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 21.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Milano Curated by ChEMBL | Assay Description The compound was tested for binding affinity on [3H]-8-OH-DPAT as specific ligand on 5-hydroxytryptamine 1A receptor in rat hippocampus | J Med Chem 42: 173-7 (1999) Article DOI: 10.1021/jm981006q BindingDB Entry DOI: 10.7270/Q22J6B05 | |||||||||||
More data for this Ligand-Target Pair |