BindingDB PrimarySearch

BDBM50074456 CHEMBL10504::SC241::[3-(2-Bromo-4-isopropyl-phenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-bis-(2-methoxy-ethyl)-amine

SMILES: COCCN(CCOC)c1nc(C)nc2n(nnc12)-c1ccc(cc1Br)C(C)C

InChI Key: InChIKey=DMJNPPHUVMMIEQ-UHFFFAOYSA-N

Data: 6 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50074456
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50074456 (CHEMBL10504 \| SC241 \| [3-(2-Bromo-4-isopropyl-phen...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Compound was tested for the inhibition of binding of the radioligand, [125 I-Tyr0]-CRF to rat cerebral cortex membrane				J Med Chem 43: 1641-60 (2000) BindingDB Entry DOI: 10.7270/Q29S1RRP
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50074456 (CHEMBL10504 \| SC241 \| [3-(2-Bromo-4-isopropyl-phen...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Antagonistic activity for Corticotropin releasing factor receptor 1				Bioorg Med Chem Lett 9: 1063-6 (1999) BindingDB Entry DOI: 10.7270/Q21V5D5N
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50074456 (CHEMBL10504 \| SC241 \| [3-(2-Bromo-4-isopropyl-phen...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Binding affinity to recombinant human Corticotropin releasing factor receptor 1 (hCRF1) expressed in 293EBNA cells				J Med Chem 42: 833-48 (1999) Article DOI: 10.1021/jm980224g BindingDB Entry DOI: 10.7270/Q2610ZGP
DuPont Pharmaceuticals Company Curated by ChEMBL					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor (Rattus norvegicus (rat))	BDBM50074456 (CHEMBL10504 \| SC241 \| [3-(2-Bromo-4-isopropyl-phen...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	14.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by PDSP K_i Database									J Pharmacol Exp Ther 289: 926-35 (1999) BindingDB Entry DOI: 10.7270/Q2GM85VG
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor (Rattus norvegicus (rat))	BDBM50074456 (CHEMBL10504 \| SC241 \| [3-(2-Bromo-4-isopropyl-phen...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	20.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by PDSP K_i Database									J Pharmacol Exp Ther 289: 926-35 (1999) BindingDB Entry DOI: 10.7270/Q2GM85VG
					More data for this Ligand-Target Pair
CRF2 Beta (RAT)	BDBM50074456 (CHEMBL10504 \| SC241 \| [3-(2-Bromo-4-isopropyl-phen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by PDSP K_i Database									J Pharmacol Exp Ther 289: 926-35 (1999) BindingDB Entry DOI: 10.7270/Q2GM85VG
					More data for this Ligand-Target Pair