BDBM50074695 CHEMBL3410160
SMILES: CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2conc2C)C1=O)c1ccccc1
InChI Key: InChIKey=XHVDMEMANOFVOM-MEKIYTOJSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Notch 1 intracellular domain (Notch 1) (Homo sapiens (Human)) | BDBM50074695 (CHEMBL3410160) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa... | Bioorg Med Chem Lett 25: 1905-9 (2015) Article DOI: 10.1016/j.bmcl.2015.03.038 BindingDB Entry DOI: 10.7270/Q2X92D18 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Notch 3 intracellular domain (Notch 3) (Homo sapiens (Human)) | BDBM50074695 (CHEMBL3410160) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development Curated by ChEMBL | Assay Description Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa... | Bioorg Med Chem Lett 25: 1905-9 (2015) Article DOI: 10.1016/j.bmcl.2015.03.038 BindingDB Entry DOI: 10.7270/Q2X92D18 | |||||||||||
More data for this Ligand-Target Pair |