BDBM50074743 3-(3-Chloro-phenyl)-5,7-dihydroxy-1H-quinolin-4-one::CHEMBL266995

SMILES: Oc1cc(O)c2c(O)c(cnc2c1)-c1cccc(Cl)c1

InChI Key: InChIKey=ZDTZOBIXVNHHCR-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50074743   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor alpha/beta (Homo sapiens (Human))	BDBM50074743 (3-(3-Chloro-phenyl)-5,7-dihydroxy-1H-quinolin-4-on...) Show SMILES Oc1cc(O)c2c(O)c(cnc2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C15H10ClNO3/c16-9-3-1-2-8(4-9)11-7-17-12-5-10(18)6-13(19)14(12)15(11)20/h1-7,18-19H,(H,17,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS Limited Curated by ChEMBL					Assay Description Inhibition of Platelet-derived growth factor receptor-dependent phosphorylation				J Med Chem 42: 1018-26 (1999) Article DOI: 10.1021/jm980551o BindingDB Entry DOI: 10.7270/Q21835PV
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50074743 (3-(3-Chloro-phenyl)-5,7-dihydroxy-1H-quinolin-4-on...) Show SMILES Oc1cc(O)c2c(O)c(cnc2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C15H10ClNO3/c16-9-3-1-2-8(4-9)11-7-17-12-5-10(18)6-13(19)14(12)15(11)20/h1-7,18-19H,(H,17,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS Limited Curated by ChEMBL					Assay Description Inhibition of Epidermal growth factor receptor-dependent phosphorylation				J Med Chem 42: 1018-26 (1999) Article DOI: 10.1021/jm980551o BindingDB Entry DOI: 10.7270/Q21835PV
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1/ABL2 (Homo sapiens (Human))	BDBM50074743 (3-(3-Chloro-phenyl)-5,7-dihydroxy-1H-quinolin-4-on...) Show SMILES Oc1cc(O)c2c(O)c(cnc2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C15H10ClNO3/c16-9-3-1-2-8(4-9)11-7-17-12-5-10(18)6-13(19)14(12)15(11)20/h1-7,18-19H,(H,17,20)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS Limited Curated by ChEMBL					Assay Description Inhibition of v-Abl tyrosine kinase				J Med Chem 42: 1018-26 (1999) Article DOI: 10.1021/jm980551o BindingDB Entry DOI: 10.7270/Q21835PV
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Mus musculus)	BDBM50074743 (3-(3-Chloro-phenyl)-5,7-dihydroxy-1H-quinolin-4-on...) Show SMILES Oc1cc(O)c2c(O)c(cnc2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C15H10ClNO3/c16-9-3-1-2-8(4-9)11-7-17-12-5-10(18)6-13(19)14(12)15(11)20/h1-7,18-19H,(H,17,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS Limited Curated by ChEMBL					Assay Description Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation				J Med Chem 42: 1018-26 (1999) Article DOI: 10.1021/jm980551o BindingDB Entry DOI: 10.7270/Q21835PV
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50074743 (3-(3-Chloro-phenyl)-5,7-dihydroxy-1H-quinolin-4-on...) Show SMILES Oc1cc(O)c2c(O)c(cnc2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C15H10ClNO3/c16-9-3-1-2-8(4-9)11-7-17-12-5-10(18)6-13(19)14(12)15(11)20/h1-7,18-19H,(H,17,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS Limited Curated by ChEMBL					Assay Description Inhibition of p60 c-Src tyrosine kinase				J Med Chem 42: 1018-26 (1999) Article DOI: 10.1021/jm980551o BindingDB Entry DOI: 10.7270/Q21835PV
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50074743 (3-(3-Chloro-phenyl)-5,7-dihydroxy-1H-quinolin-4-on...) Show SMILES Oc1cc(O)c2c(O)c(cnc2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C15H10ClNO3/c16-9-3-1-2-8(4-9)11-7-17-12-5-10(18)6-13(19)14(12)15(11)20/h1-7,18-19H,(H,17,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS Limited Curated by ChEMBL					Assay Description Inhibition of Epidermal growth factor receptor-dependent phosphorylation				J Med Chem 42: 1018-26 (1999) Article DOI: 10.1021/jm980551o BindingDB Entry DOI: 10.7270/Q21835PV
					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50074743 (3-(3-Chloro-phenyl)-5,7-dihydroxy-1H-quinolin-4-on...) Show SMILES Oc1cc(O)c2c(O)c(cnc2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C15H10ClNO3/c16-9-3-1-2-8(4-9)11-7-17-12-5-10(18)6-13(19)14(12)15(11)20/h1-7,18-19H,(H,17,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS Limited Curated by ChEMBL					Assay Description Inhibition of Protein kinase C alpha				J Med Chem 42: 1018-26 (1999) Article DOI: 10.1021/jm980551o BindingDB Entry DOI: 10.7270/Q21835PV
					More data for this Ligand-Target Pair