BDBM50075000 (E)-N-({[4-Chloro-2-cyano-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-methyl-carbamoyl}-methyl)-3-(3-methoxy-phenyl)-acrylamide::CHEMBL113963
SMILES: COc1cccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2C#N)c1
InChI Key: InChIKey=LRFPQMIXTRKWGR-RVDMUPIBSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bradykinin B2 receptor (Cavia porcellus) | BDBM50075000 ((E)-N-({[4-Chloro-2-cyano-3-(2-methyl-quinolin-8-y...) | MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Marion Roussel GmbH Curated by ChEMBL | Assay Description Inhibition of specific binding of [3H]-BK to bradykinin B2 receptors of guinea pig ileum (GPI) | Bioorg Med Chem Lett 9: 327-32 (1999) BindingDB Entry DOI: 10.7270/Q2416W7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bradykinin B2 receptor (Cavia porcellus) | BDBM50075000 ((E)-N-({[4-Chloro-2-cyano-3-(2-methyl-quinolin-8-y...) | MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a |
Hoechst Marion Roussel GmbH Curated by ChEMBL | Assay Description Inhibition of specific binding of [3H]-BK to bradykinin B2 receptors of guinea pig ileum (GPI) | Bioorg Med Chem Lett 9: 327-32 (1999) BindingDB Entry DOI: 10.7270/Q2416W7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bradykinin B2 receptor (Cavia porcellus) | BDBM50075000 ((E)-N-({[4-Chloro-2-cyano-3-(2-methyl-quinolin-8-y...) | MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst Marion Roussel GmbH Curated by ChEMBL | Assay Description Inhibition of specific binding of [3H]-BK to bradykinin B2 receptors of guinea pig ileum (GPI) | Bioorg Med Chem Lett 9: 327-32 (1999) BindingDB Entry DOI: 10.7270/Q2416W7C | |||||||||||
More data for this Ligand-Target Pair |