BDBM50075673 2-(4-Chloro-3-fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-cyclopent-2-enone::CHEMBL23175

SMILES: CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)CC1)c1ccc(Cl)c(F)c1

InChI Key: InChIKey=GAAWMIACGLOHRF-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50075673   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50075673 (2-(4-Chloro-3-fluoro-phenyl)-3-(4-methanesulfonyl-...) Show SMILES CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)CC1)c1ccc(Cl)c(F)c1 |t:11| Show InChI InChI=1S/C18H14ClFO3S/c1-24(22,23)13-5-2-11(3-6-13)14-7-9-17(21)18(14)12-4-8-15(19)16(20)10-12/h2-6,8,10H,7,9H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description In vitro potency against human Prostaglandin G/H synthase 1 in U937 microsomes .				J Med Chem 42: 1274-81 (1999) Article DOI: 10.1021/jm980642l BindingDB Entry DOI: 10.7270/Q21V5FNB
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50075673 (2-(4-Chloro-3-fluoro-phenyl)-3-(4-methanesulfonyl-...) Show SMILES CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)CC1)c1ccc(Cl)c(F)c1 |t:11| Show InChI InChI=1S/C18H14ClFO3S/c1-24(22,23)13-5-2-11(3-6-13)14-7-9-17(21)18(14)12-4-8-15(19)16(20)10-12/h2-6,8,10H,7,9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description In vitro potency against human Prostaglandin G/H synthase 2 in transfected CHO cells.				J Med Chem 42: 1274-81 (1999) Article DOI: 10.1021/jm980642l BindingDB Entry DOI: 10.7270/Q21V5FNB
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50075673 (2-(4-Chloro-3-fluoro-phenyl)-3-(4-methanesulfonyl-...) Show SMILES CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)CC1)c1ccc(Cl)c(F)c1 |t:11| Show InChI InChI=1S/C18H14ClFO3S/c1-24(22,23)13-5-2-11(3-6-13)14-7-9-17(21)18(14)12-4-8-15(19)16(20)10-12/h2-6,8,10H,7,9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.				J Med Chem 42: 1274-81 (1999) Article DOI: 10.1021/jm980642l BindingDB Entry DOI: 10.7270/Q21V5FNB
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM50075673 (2-(4-Chloro-3-fluoro-phenyl)-3-(4-methanesulfonyl-...) Show SMILES CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)CC1)c1ccc(Cl)c(F)c1 |t:11| Show InChI InChI=1S/C18H14ClFO3S/c1-24(22,23)13-5-2-11(3-6-13)14-7-9-17(21)18(14)12-4-8-15(19)16(20)10-12/h2-6,8,10H,7,9H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description In vitro potency against human Prostaglandin G/H synthase 1 (hCOX-1) in the human whole blood assay.				J Med Chem 42: 1274-81 (1999) Article DOI: 10.1021/jm980642l BindingDB Entry DOI: 10.7270/Q21V5FNB
					More data for this Ligand-Target Pair