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SMILES: CCCN(CC1CC1)c1nc(C)nc2n(-c3c(C)cc(C)cc3C)c(=O)n(C)c12

InChI Key: InChIKey=LWZGRKIVVJLGEJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50076624   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50076624
PNG
(6-(Cyclopropylmethyl-propyl-amino)-2,7-dimethyl-9-...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc2n(-c3c(C)cc(C)cc3C)c(=O)n(C)c12 |(3.16,.16,;4.49,-.61,;4.5,-2.15,;5.84,-2.92,;7.19,-2.15,;7.17,-.61,;7.94,.72,;6.4,.72,;5.86,-4.46,;4.53,-5.23,;4.53,-6.77,;3.18,-7.54,;5.86,-7.54,;7.19,-6.77,;8.66,-7.23,;9.15,-8.69,;10.65,-8.99,;11.67,-7.82,;11.14,-10.45,;10.11,-11.6,;10.6,-13.07,;8.61,-11.3,;8.13,-9.83,;6.61,-9.52,;9.57,-5.98,;11.11,-5.97,;8.66,-4.74,;9.12,-3.27,;7.19,-5.23,)|
Show InChI InChI=1S/C23H31N5O/c1-7-10-27(13-18-8-9-18)21-20-22(25-17(5)24-21)28(23(29)26(20)6)19-15(3)11-14(2)12-16(19)4/h11-12,18H,7-10,13H2,1-6H3
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MMDB

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PubMed
 6.10n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for transfected human Corticotropin releasing factor receptor expressed in HEK 293E cells using [125I]-TYR-oCRH as the displaced rad...

Bioorg Med Chem Lett 9: 967-72 (1999)


BindingDB Entry DOI: 10.7270/Q26H4GKK
More data for this
Ligand-Target Pair